Downregulation of miR-503 Promotes ESCC Cell Proliferation,Migration,and Invasion by Targeting Cyclin D1

查看全文 作　　者：Lanfang [1]Jiang;Zitong [1]Zhao;Leilei [1]Zheng;Liyan [1]Xue;Qimin [1]Zhan;Yongmei [1]Song

机构地区：[1]State Key Laboratory of Molecular Oncology,National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China

出　　处：《Genomics, Proteomics & Bioinformatics》索引2017年第15卷第3期,共10页

基　　金：supported by the funding from the National Natural Science Foundation of China(Grant Nos.81472661 and 81402463);CAMS Innovation Fund for Medical Sciences(CIFMS;Grant No.2016-I2M-1-001) 摘　　要：Esophageal squamous cell carcinoma(ESCC) is one of the most aggressive cancers in China,but the underlying molecular mechanism of ESCC is still unclear.Involvement of microRNAs has been demonstrated in cancer initiation and progression.Despite the reported function of miR-503 in several human cancers,its detailed anti-oncogenic role and clinical significance in ESCC remain undefined.In this study,we examined miR-503 expression by q PCR and found the downregulation of miR-503 expression in ESCC tissue relative to adjacent normal tissues.Further investigation in the effect of miR-503 on ESCC cell proliferation,migration,and invasion showed that enhanced expression of miR-503 inhibited ESCC aggressive phenotype and overexpression of CCND1 reversed the effect of miR-503-mediated ESCC cell aggressive phenotype.Our study further identified CCND1 as the target gene of miR-503.Thus,miR-503 functions as a tumor suppressor and has an important role in ESCC by targeting CCND1. 关键词：食管癌细胞细胞周期蛋白D1 侵袭性增殖迁移抗肿瘤作用肿瘤抑制基因鳞状细胞癌

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Downregulation of miR-503 Promotes ESCC Cell Proliferation,Migration,and Invasion by Targeting Cyclin D1

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