Immunological effect of local ablation combined with immunotherapy on solid malignancies

查看全文 作　　者：Yusuke [1]Takahashi;Noriyuki [1]Matsutani;Takashi [1]Nakayama;Hitoshi [1]Dejima;Hirofumi [1]Uehara;Masafumi [1]Kawamura

机构地区：[1]Department of General Thoracic Surgery,Teikyo University School of Medicine

出　　处：《Chinese Journal of Cancer》索引2017年第36卷第6期,共6页

摘　　要：Recent comprehensive investigations clarified that immune microenvironment surrounding tumor cells are deeply involved in tumor progression,metastasis,and response to treatment.Furthermore,several immunotherapeutic trials have achieved successful results,and the immunotherapeutic agents are available in clinical practice.To enhance their demonstrated efficacy,combination of immunotherapy and ablation has begun to emerge.Local ablations have considerable advantages as an alternative therapeutic option,especially its minimal invasiveness.In addition,local ablations have shown immune-regulatory effect in preclinical and clinical studies.Although the corresponding mechanisms are still unclear,the local ablations combined with immunotherapy have been suggested in the treatment of several solid malignancies.This article aims to review the published data on the immune-regulatory effects of local ablations including stereotactic body radiotherapy,cryoablation,radiofrequency ablation,and high-intensityfocused ultrasound.We also discuss the value of local ablations combined with immunotherapy.Local ablations have the potential to improve future patient outcomes;however,the effectiveness and safety of local ablations combined with immunotherapy should be further investigated. 关键词：免疫治疗剂免疫效应实体瘤免疫调节作用高强度聚焦超声肿瘤细胞临床实践综合调查

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Immunological effect of local ablation combined with immunotherapy on solid malignancies

参考文献(94)

引证文献(7)

耦合文献(15)

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