Targeting sphingosine-1-phosphate signaling for cancer therapy

查看全文 作　　者：Zuoquan [1]Xie;Hong [2]Liu;Meiyu [1]Geng

机构地区：[1]Division of Antitumor Pharmacology,State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;[2]Division of Chemistry,State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China

出　　处：《Science China(Life Sciences)》索引2017年第60卷第6期,共16页

基　　金：financial support from the National Natural Science Foundation of China(91229204);the Major Project of the Chinese National Programs for Fundamental Research and Development(2015CB910304) 摘　　要：Sphingosine-1-phosphate(S1P) is a potent pleotropic bioactive lipid mediator involved in immune cell trafficking, cell survival,cell proliferation, cell migration, angiogenesis and many other cellular processes. S1 P either activates S1 P receptors(S1PR1-5) through 'inside-out signaling' or acts directly on intracellular targets to regulate various cellular processes. In the past two decades, much progress has been made in exploring S1 P signaling and its pathogenic roles in diseases as well as in developing modulators of S1 P signaling, including S1 P agonists, S1 P antagonists and sphingosine kinase(SphK) inhibitors.Ceramide and S1 P have been defined as reciprocal regulators of cell fate, and S1 P signaling has been shown to be crucial for the pathogenesis of various diseases, including autoimmune diseases, inflammation and cancer; therefore, targeting S1 P signaling may curtail the process of pathogenesis and serve as a potential therapeutic target for the treatment of these diseases. In this review, we describe recent advances in our understanding of S1 P signaling in cancer development(particularly in inflammationassociated cancer) as well as in innate and adaptive immunity, and we also discuss modulators of S1 P signaling in cancer treatment. 关键词：1-磷酸鞘氨醇靶向治疗信号癌症自身免疫性疾病免疫细胞受体激动剂细胞存活率

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Targeting sphingosine-1-phosphate signaling for cancer therapy

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