Antiplatelet aggregation activity of some ferrocenylphenylimine compounds

查看全文 作　　者：Monisola [1]I.Ikhile;Foluso [2]O.Osunsanmi;Andy [2]R.Opoku;J.Catherine [1]Ngila

机构地区：[1]Department of Applied Chemistry,University of Johannesburg,Doornfontein Campus;[2]Department of Biochemistry and Microbiology,University of Zululand,private Bag X1001

出　　处：《Journal of Chinese Pharmaceutical Sciences》索引2017年第26卷第6期,共5页

基　　金：Global Excellence and Stature(GES),2016,University of Johannesburg 摘　　要：Platelet hyper-aggregability triggered death and disability due to cardiovascular diseases is increasing worldwide and becoming a global concern. Therefore, it is necessary to synthesize newer drugs for the management of platelet aggregation. In this study, we investigated the antiplatelet aggregation activity of a novel series of ferrocenylimine compounds(3–10), N-(3-nitro-2-hydroxylbenzylidene)-3-ferrocenylimine(3), N-(3-bromo-2-hydroxylbenzylidene)-3-ferrocenylimine(4), N-(3-bromo-5-chlorosalicylidene)-3-ferrocenylimine(5), N-(ferrocenylformidene)-3-ferrocenylimine(6), N-(3-nitro-2-hydroxylbenzylidene)-4-ferrocenylimine(7), N-(3-bromo-2-hydroxylbenzylidene)-4-ferrocenylimine(8), N-(3-bromo-5-chlorosalicyl)-4-ferrocenylimine(9), N-(ferrocenylformidene)-4-ferrocenylimine(10) on thrombin-and ADP-induced platelet aggregation. The synthesized ferrocenylimine compounds(3–10) were found to exhibit higher antiplatelet aggregation activity than their precursors, which are 3-ferrocenylaniline(compound 1) and 4-ferrocenylaniline(compound 2). Among the derivatives, compounds 5, 6 and 10 possessed excellent platelet aggregation inhibition against the agonists. 关键词：FERROCENE IMINE Antiplatelet aggregation THROMBIN PLATELET

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Antiplatelet aggregation activity of some ferrocenylphenylimine compounds

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