Gastrodin Attenuates Pentylenetetrazole-Induced Seizures by Modulating the Mitogen-Activated Protein Kinase-Associated Inflammatory Responses in Mice

查看全文 作　　者：Liming [1]Chen;Xinan [3]Liu;Hua [1]Wang;Min [2]Qu

机构地区：[1]Neurology Department,The First People's Hospital of Jingzhou,The First Affiliated Hospital of Yangtze University,Jingzhou 434000,China;[2]Hubei Provincial Key Laboratory for Applied Toxicology,Hubei Provincial Center for Disease Control and Prevention,Wuban 430079,China;[3]Department of Neuroscience,lcahn School of Medicine at Mount Sinai,New York,NY 10029,USA

出　　处：《Neuroscience Bulletin》索引2017年第33卷第3期,共9页

摘　　要：Gastrodin, the major component isolated from the rhizome of the Chinese traditional medicinal herb Gastrodia elata(‘‘Tianma''), has a long history in the treatment of epilepsy and other neurological disorders.However, the molecular mechanisms are not clear. Here,we found that gastrodin ameliorated pentylenetetrazole(PTZ)-induced epileptic seizures with improvement of the electroencephalographic pattern in mice. Further studies demonstrated that gastrodin decreased the levels of the pro-inflammatory cytokines interleukin-1b and tumor necrosis factor-a while increasing interleukin-10, an antiinflammatory cytokine in the brain. Furthermore, gastrodin attenuated the PTZ-induced microglial activation along with inhibition of mitogen-activated protein kinases,c AMP response element binding protein, and NF-j B. Our data suggest that gastrodin attenuates seizures by modulating the mitogen-activated protein kinase-associated inflammatory responses. 关键词：丝裂原活化蛋白激酶炎症反应天麻素癫痫 CAMP反应元件结合蛋白小鼠四唑促分裂原活化蛋白激酶

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Gastrodin Attenuates Pentylenetetrazole-Induced Seizures by Modulating the Mitogen-Activated Protein Kinase-Associated Inflammatory Responses in Mice

参考文献(73)

引证文献(41)

耦合文献(13)

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