Low hypoxia inducible factor-1α(HIF-1α)expression in testicular germ cell tumors--a major reason for enhanced chemosensitivity?

查看全文 作　　者：niraj [1]shenoy;roxana [1]dronca;fernando [1]quevedo;stephen a [2]boorjian;john [3]cheville;brian [1]costello;manish [1]kohli;thomas [1]witzig;lance [1]pagliaro

机构地区：[1]division of oncology,mayo clinic,Rochester,MN 55905,usa;[2]department of urology,mayo clinic,Rochester,MN 55905,usa;[3]division of clinical pathology,mayo clinic,Rochester,MN 55905,usa

出　　处：《Chinese Journal of Cancer Research》索引2017年第29卷第4期,共5页

摘　　要：The molecular basis for enhanced chemosensitivity of testicular germ cell tumors(GCT)has been an area of great interest,as it could potentially give us therapeutic leads in other resistant malignancies.Thus far,however,the increased sensitivity of GCT has been variously attributed to multiple factors—an inability to detoxify cisplatin,a lack of export pumps,an inability to repair the DNA damage,an intact apoptotic cascade and lack of p53 mutation;but a unifying underlying etiology leading to the aforementioned processes and having a translational implication has so far been elusive.Herein,we offer evidence to support a potential significant role for the previously demonstrated low hypoxia inducible factor-1α(HIF-1α)expression in mediating the general exquisite chemosensitivity of testicular GCT,through the aforementioned processes.This molecular mechanism based hypothesis could have a significant translational implication in platinum refractory GCT as well as other platinum resistant malignancies. 关键词：缺氧诱导因子-1Α 睾丸生殖细胞 HIF-1Α 恶性肿瘤敏感性化疗 P53基因突变低压

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Low hypoxia inducible factor-1α(HIF-1α)expression in testicular germ cell tumors--a major reason for enhanced chemosensitivity?

参考文献(36)

引证文献(5)

耦合文献(45)

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