Artificial periosteum in bone defect repair--A review

查看全文 作　　者：Quan [1,3]Wang;Jianxiang [1]Xu;Haiming [1]Jin;Wenhao [1]Zheng;Xiaolei [1,3]Zhang;Yixing [1]Huang;Zhiyong [1,2]Qian

机构地区：[1]Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China;[2]Department of Oncology and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China;[3]Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325027, China

出　　处：《Chinese Chemical Letters》索引2017年第28卷第9期,共7页

基　　金：financially supported by National Natural Science Foundation of China(Nos.31525009 and 31271021);National 863 Project(No.2015AA020316);Sichuan Innovative Research Team Program for Young Scientists(No.2016TD0004);Zhejiang Provincial Science and Technology Grant(No.2017C33100);Zhejiang Provincial Natural Science Foundation of China(No.LY17H060010) 摘　　要：Periosteum is a thin membrane that encases the surfaces of most bones.It is composed of an outer fibrous layer contains longitudinally oriented cells and collagen fibers and an inner cambial layer that consists of multipotent mesenchymal stem cells(MSCs)and osteogenic progenitor cells.Periosteum has a function of regulating cell and collagen arrangement,which is important to the integrity,modelling and remodelling of bone,particularly during bone defect repair.Apart from autograft and allograft,artificial periosteum,or tissue-engineered periosteum mimicking native periosteum in structure or function,made up of small intestinal submucosa,acellular dermis,induced membrane,cell sheets,and polymeric scaffolds,and so on,has been developed to be used in bone defect repair.In this review,we classify the artificial periosteum into three approaches based on the material source,that is,native tissues,scaffoldfree cell sheets and scaffold-cell composites.Mechanisms,methods and efficacy of each approach are provided.Existing obstacles and enabling technologies for future directions are also discussed. 关键词：骨缺损骨膜修复人工应用间充质干细胞胶原纤维组织工程

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Artificial periosteum in bone defect repair--A review

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