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Concordance among indices of intrinsic brain function: Insights from inter-individual variation and temporal dynamics

查看全文 作　　者：Chao-Gan [1,2,3,4,5,6]Yan;Zhen [5,7,8]Yang;Stanley J. [5]Colcombe;Xi-Nian [1,2,3,4]Zuo;Michael P. [5,8]Milham 高影响力作者 机构地区：[1]CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China;[2]Departrnent of Psychology, University of Chinese Academy of Sciences, Beijing 100101, China;[3]Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China;[4]center for Lifespan Innovation of Mind and Brain, Institute of Psychology, Chinese Academy of Sciences, Beijing, China;[5]Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA;[6]Department of Child and Adolescent Psychiatry, NYU Langone Medical Center School of Medicine, New York, NY 10016, USA;[7]Center for Neuromodulation in Depression and Stress, Department of Psychiatry, Perelman School of Medidne, University of Pennsylvania, Philadelphia, PA 19104, USA;[8]Child Mind Institute, New York, NY 10022, USA高影响力机构 出　　处：《Science Bulletin》索引2017年第62卷第23期,共13页高影响力期刊 基　　金：supported by the National Key R&D Program of China (2017YFC1309902 to CGY);National Basic Research Program (2015CB351702 to XNZ);the Natural Science Foundation of China (81671774 and 81630031 to CGY, 81471740, 81220108014 to XNZ);the Hundred Talents Program of the Chinese Academy of Sciences (Y5CX072006 to CGY);Beijing Municipal Science & Technology Commission (Z161100000216152 to CGY);the National Institutes of Health (U01MH099059 to MPM);the Child Mind Institute (1FDN2012-1 to MPM) 摘　　要：Various resting-state fMRI(R-fMRI) measures have been developed to characterize intrinsic brain activity. While each of these measures has gained a growing presence in the literature, questions remain regarding the common and unique aspects these indices capture. The present work provided a comprehensive examination of inter-individual variation and intra-individual temporal variation for commonly used measures, including fractional amplitude of low frequency fluctuations, regional homogeneity,voxel-mirrored homotopic connectivity, network centrality and global signal correlation. Regardless of whether examining intra-individual or inter-individual variation, we found that these definitionally distinct R-fMRI indices tend to exhibit a relatively high degree of covariation, which doesn't exist in phase randomized surrogate data. As a measure of intrinsic brain function, concordance for R-fMRI indices was negatively correlated with age across individuals(i.e., concordance among functional indices decreased with age). To understand the functional significance of concordance, we noted that higher concordance was generally associated with higher strengths of R-fMRI indices, regardless of whether looking through the lens of inter-individual(i.e., high vs. low concordance participants) or intra-individual(i.e., high vs.low concordance states identified via temporal dynamic analyses) differences. We also noted a linear increase in functional concordance together with the R-fMRI indices through the scan, which may suggest a decrease in arousal. The current study demonstrated an enriched picture regarding the relationship among the R-fMRI indices, as well as provided new insights in examining dynamic states within and between individuals. 关 键 词：Resting-state fMRI Intrinsic brain activity CONCORDANCE Temporal dynamics Inter-individual variation
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