Novel triterpene saponins isolated from Clematis mandshurica and their inhibitory activities on NO production

查看全文 作　　者：FU [1]Qiang;YANG [1]Min;MA [1]Yu;CHEN [1]Jiang;YUAN Hai-[1]Mei

机构地区：[1]College of Pharmacy and Biological Engineering, Chengdu University

出　　处：《Chinese Journal of Natural Medicines》索引2018年第16卷第2期,共8页

基　　金：supported by the National Natural Science Foundation of China(No.81503234) 摘　　要：Four new triterpene saponins, mandshunosides F–I(1–4), together with five known compounds(5–9), were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidences and hydrolysis products. Bisdesmosidic saponin(3–9) showed modest suppression of NO production with the inhibition ratios in the range of 51.3%– 64.6% at 50 μmol·L^(-1), whereas monodesmosidic saponins with a free carboxyl group at C-28(1 and 2) showed potent inhibitory activities with IC_(50) values being 12.7 and 8.3 μmol·L^(-1), respectively. 关键词：CLEMATIS mandshurica TRITERPENE SAPONINS Mandshunosides F—I NO production

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Novel triterpene saponins isolated from Clematis mandshurica and their inhibitory activities on NO production

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