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Relationship between metabolic enzyme activities and bioaccumulation kinetics of PAHs in zebrafish(Danio rerio)

查看全文 作　　者：Haotian [1]Wang;Yayuan [1]Li;Xinghui [1]Xia;Xinyue [1]Xiong 高影响力作者 机构地区：[1]State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University高影响力机构 出　　处：《Journal of Environmental Sciences》索引2018年第30卷第3期,共10页高影响力期刊 基　　金：supported by the National Science Foundation for Distinguished Young Scholars (No.51325902);the National Natural Science Foundation of China (No.91547207);the National Natural Science Foundation for Innovative Research Group (No.51421065) 摘　　要：Many studies have investigated bioaccumulation and metabolism of polycyclic aromatic hydrocarbons(PAHs)in aquatic organisms.However,lack of studies investigated both processes simultaneously,and the interaction between these two processes is less understood so far.This study investigated the bioaccumulation kinetics of PAHs and metabolic enzyme activities,including total cytochrome P450(CYPs)and total superoxide dismutase(T-SOD),in zebrafish.Mature zebrafish were exposed to the mixture of phenanthrene and anthracene under constant concentration maintained by passive dosing systems for 16 days.The results showed that PAH concentrations in zebrafish experienced a peak value after exposure for 1.5 days,and then decreased gradually.The bioaccumulation equilibrium was achieved after exposure for 12 days.Both of the uptake rate constants(k_u)and the elimination rate constants(k_e)decreased after the peak value.The variation of PAH concentrations and metabolic enzyme activities in zebrafish had an interactive relationship.The activities of CYPs and T-SOD increased initially with the increase of PAH concentrations,but decreased to the lowest state when PAH concentrations reached the peak value.When the bioaccumulation equilibrium of PAHs was achieved,CYPs and T-SOD activities also reached the steady state.In general,CYPs and T-SOD activities were activated after exposure to PAHs.The decrease of PAH concentrations in zebrafish after the peak value may be attributed to the great drop of k_uand the variation of CYPs activities.This study suggests that an interactive relationship exists between bioaccumulation kinetics of PAHs and metabolic enzyme activities in aquatic organisms. 关 键 词：新陈代谢 动力学 酶活 相互作用 细胞色素 P450 CYP
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