Elevated preoperative plasma D-dimer dose not adversely affect survival of gastric cancer after gastrectomy with curative intent: A propensity score analysis

查看全文 作　　者：Yuexiang [1]Liang;Donglei [1]He;Liangliang [2]Wu;Xuewei [2]Ding;Xiaona [2]Wang;Baogui [2]Wang;Rupeng [2]Zhang;Han [2]Liang

机构地区：[1]Department of Gastrointestinal Oncology, the First Affiliated Hospital of Hainan Medical College;[2]Department of Gastric Cancer, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Cancer, Tianjin's Clinical Research Cancer for Cancer, Key Laboratory of Cancer Prevention and Therapy

出　　处：《Chinese Journal of Cancer Research》索引2018年第30卷第2期,共9页

摘　　要：Objective: Elevated plasma D-dimer has been reported to be associated with advanced tumor stage and poor survival in several types of malignancies. The purpose of this study was to assess the potential impact of preoperative plasma D-dimer level(PDL) on overall survival(OS) of gastric cancer(GC) patients undergoing curative surgery by applying propensity score analysis.Methods: A total of 1,025 curatively resected GC patients in Tianjin Medical University Cancer Institute &Hospital were enrolled. Patients were categorized into two groups based on preoperative PDL: the elevated group(EG) and the normal group(NG). To overcome bias due to the different distribution of covariates for the two groups, a one-to-one match was applied using propensity score analysis, after matching, prognostic factors were analyzed.Results: In analysis for the whole study series, patients in the EG were more likely to have a larger proportion of tumor size ≥5 cm(67.5% vs. 55.8%, P=0.006), elder mean age(64.0±10.8 years vs. 60.5±11.6 years, P<0.001) and advanced tumor(T), node(N), and TNM stage. Patients with elevated PDL demonstrated a significantly lower 5-year OS than those with normal PDL(27.0% vs. 42.6%, P<0.001), however, the PDL was not an independent prognostic factor for OS in multivariate analysis [hazard ratio: 1.13, 95% confidence interval(95% CI): 0.92–1.39,P=0.236]. After matching, 163 patients in the EG and 163 patients in the NG had the same characteristics. The 5-year OS rate for patients in the EG was 27.0% compared with 25.8% for those in the NG(P=0.809, log-rank).Conclusions: The poor prognosis of GC patients with elevated preoperative PDL was due to the advanced tumor stage and elder age rather than the elevated D-dimer itself. 关键词：外科手术血浆癌症药品页面描述语言剂量分数胃

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Elevated preoperative plasma D-dimer dose not adversely affect survival of gastric cancer after gastrectomy with curative intent: A propensity score analysis

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