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Characteristics of distribution of Mycobacterium tuberculosis lineages in China

查看全文 作　　者：Haixia [1,2]Chen;Li [3,4]He;Chao [5]Cai;Jingyi [1,2]Liu;Junnan [2,5,6]Jia;Liang [7]Ma;Hairong [2,5]Huang;Lixia [8]Wang;Xumin [9]Ni;Jimin [1]Gao;Weimin [2,5,6]Li 高影响力作者 机构地区：[1]Zhejiang Provincial Key Laboratory for Technology and Application of Model Organisms, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, China;[2]National Tuberculosis Clinical Lab of China, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China;[3]Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, China;[4]School of Mathematical Sciences, Univsersity of Chinese Academy of Sciences, Beijing 100049, China;[5]Beijing Key Laboratory in Drug Resistance Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China;[6]Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, China;[7]Beijing Institute of Genomies, Chinese Academy of Sciences, Bering 100101, China;[8]National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China;[9]Department of Mathematics, School of Science, Beijing Jiaotong University, Beijing 100044, China高影响力机构 出　　处：《Science China(Life Sciences)》索引2018年第61卷第6期,共9页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China(81273144);Beijing Natural Science Foundation Program and Scientific Research Key Program of Beijing Municipal Commission of Education(KZ201510025024);the Fundamental Research Funds for the Central Universities(2017JBM071);the China Postdoctoral Science Foundation(2017M620595) 摘　　要：The genotyping methods of Mycobacterium tuberculosis would dramatically improve our understanding of the molecular epidemiology of tuberculosis. 3,929 isolates, from a National Survey of Drug-Resistant Tuberculosis in 2007 in China, were successfully genotyped by large sequence polymorphisms and 15 loci variable number tandem repeats. We found that 2,905(2,905/3,929, 73.9%) cases belonged to Lineage 2, dominated in the east and central regions, 975 cases(975/3,929, 24.8%) were Lineage 4, highly prevailed in the west regions, and 36 and 13 cases were Lineage 3 and Lineage 1, respectively. We also explored the associations between lineages(Lineage 2 vs. Lineage 4) and clinical characteristics by logistic regression. For Lineage 2, the risk factors were Han-ethnicity population and fever. However, for Lineage 4, they were occupation(farmer), and degree of education(non-literate). Fully understanding of the distribution of Mycobacterium tuberculosis lineage and its risk factors would play a critical role in tuberculosis prevention, control, and treatment. 关 键 词：MYCOBACTERIUM 肺结核 中国 特征 分发 风险因素 传染病学 中央区域
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