Effects of repetitive transcranial magnetic stimulation on cognitive function and cholinergic activity in the rat hippocampus after vascular dementia

查看全文 作　　者：Xiao-Qiao [1]Zhang;Li [2]Li;Jiang-Tao [1]Huo;Min [1]Cheng;Lin-Hong [1]Li

机构地区：[1]Department of General Medicine & Neurology, Taihe Hospital, Hubei University of Medicine;[2]Department of Pharmacy, Taihe Hospital, Hubei University of Medicine

出　　处：《Neural Regeneration Research》索引2018年第13卷第8期,共6页

基　　金：supported by a grant from the Major Project of Educational Commission of Hubei Province of China,No.D20152101 摘　　要：Repetitive transcranial magnetic stimulation(rTMS) is a non-invasive treatment that can enhance the recovery of neurological function after stroke. Whether it can similarly promote the recovery of cognitive function after vascular dementia remains unknown. In this study, a rat model for vascular dementia was established by the two-vessel occlusion method. Two days after injury, 30 pulses of rTMS were administered to each cerebral hemisphere at a frequency of 0.5 Hz and a magnetic field intensity of 1.33 T. The Morris water maze test was used to evaluate learning and memory function. The Karnovsky-Roots method was performed to determine the density of cholinergic neurons in the hippocampal CA1 region. Immunohistochemical staining was used to determine the number of brain-derived neurotrophic factor(BDNF)-immunoreactive cells in the hippocampal CA1 region. rTMS treatment for 30 days significantly improved learning and memory function, increased acetylcholinesterase and choline acetyltransferase activity, increased the density of cholinergic neurons, and increased the number of BDNF-immunoreactive cells. These results indicate that r TMS can ameliorate learning and memory deficiencies in rats with vascular dementia. The mechanism through which this occurs might be related to the promotion of BDNF expression and subsequent restoration of cholinergic system activity in hippocampal CA1 region. 关键词：认知功能胆碱能痴呆脉管老鼠磁性怪兽鱼尾

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Effects of repetitive transcranial magnetic stimulation on cognitive function and cholinergic activity in the rat hippocampus after vascular dementia

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引证文献(38)

耦合文献(54)

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