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Glial fibrillary acidic protein levels are associated with global histone H4 acetylation after spinal cord injury in rats

查看全文 作　　者：Mayara Ferraz de [1,2]Menezes;Fabricio [3]Nicola;Ivy Reichert Vital da [4]Silva;Adriana [3]Vizuete;Viviane Rostirola [4]Eisner;Leder Leal [1,2]Xavier;Carlos Alberto Saraiva [3]Goncalves;Carlos Alexandre [3]Netto;Regis Gemerasca [1,2]Mestriner 高影响力作者 机构地区：[1]Neurorehabilitation and Neural Repair Research Group, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brazil;[2]Graduate Program in Cellular and Molecular Biology, Pontificia Universidade Catolica do Rio Grande do SUl, Porto Alegre, RS, Brazil;[3]Department of Biochemistry, Basic Science Institute, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil;[4]Graduate Program in Biosciences and Rehabilitation. Centro Universitairio Metodista IPA, Porto Alegre, RS, Brazil高影响力机构 出　　处：《Neural Regeneration Research》索引2018年第13卷第11期,共8页高影响力期刊 基　　金：supported by Brazilian funding agencies CNPq,CAPES and FAPERGS 摘　　要：Emerging evidence has suggested global histone H4 acetylation status plays an important role in neural plasticity. For instance, the imbalance of this epigenetic marker has been hypothesized as a key factor for the development and progression of several neurological diseases. Likewise, astrocytic reactivity-a wellknown process that markedly influences the tissue remodeling after a central nervous system injury-is crucial for tissue remodeling after spinal cord injury(SCI). However, the linkage between the above-mentioned mechanisms after SCI remains poorly understood. We sought to investigate the relation between both glial fibrillary acidic protein(GFAP) and S100 calcium-binding protein B(S100B)(astrocytic reactivity classical markers) and global histone H4 acetylation levels. Sixty-one male Wistar rats(aged ~3 months) were divided into the following groups: sham; 6 hours post-SCI; 24 hours post-SCI; 48 hours post-SCI; 72 hours post-SCI; and 7 days post-SCI. The results suggested that GFAP, but not S100B was associated with global histone H4 acetylation levels. Moreover, global histone H4 acetylation levels exhibited a complex pattern after SCI, encompassing at least three clearly defined phases(first phase: no changes in the 6, 24 and 48 hours post-SCI groups; second phase: increased levels in the 72 hours post-SCI group; and a third phase: return to levels similar to control in the 7 days post-SCI group). Overall, these findings suggest global H4 acetylation levels exhibit distinct patterns of expression during the first week post-SCI, which may be associated with GFAP levels in the perilesional tissue. Current data encourage studies using H4 acetylation as a possible biomarker for tissue remodeling after spinal cord injury. 关 键 词：蛋白质 损害 绳索 老鼠 WISTAR GFAP 神经系统 S100
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