Stems and leaves of Aconitum carmichaelii Debx.as potential herbal resources for treating rheumatoid arthritis: Chemical analysis,toxicity and activity evaluation

查看全文 作　　者：HE Ya-[1]Nan;OU Shui-[1,2]Ping;XIONG [1]Xi;PAN [1]Yuan;PEI [1,3]Jin;XU Run-[1]Chun;GENG Fu-[3]Neng;HAN [1]Li;ZHANG Ding-[1,3]Kun;YANG [4]Ming

机构地区：[1]State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;[2]Affiliated Hospital of Zunyi Medical College, Zunyi 563000, China;[3]Sichuan Good Doctor Panxi Pharmaceutical Co., Ltd., Xiehang 615000, China;[4]Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China

出　　处：《Chinese Journal of Natural Medicines》索引2018年第16卷第9期,共9页

基　　金：supported by the Sichuan Provincial Administration of Traditional Chinese Medicine Research Project(No.2018NQ008) 摘　　要：According to folk usage of Aconitum carmichaelii Debx., the present study was designed to determine the feasibility of the stems and leaves of Aconitum carmichaelii Debx. as a new medicinal resource. Fourteen alkaloids in mother roots, fibrous roots, stems, and leaves of Aconitum carmichaelii Debx. were measured by HPLC-MS/MS. And multivariate analysis methods, such as clustering analysis and principal component analysis, were applied to analyze the difference among various parts. In addition, the acute toxicity, analgesia, and anti-inflammatory tests were carried out. The results suggested that the contents of alkaloids in mother roots and fibrous roots were approximate, but those of leaves and stems were different from mother roots and fibrous roots. The results of the acute toxicity testing demonstrated the toxicity of fibrous root was strongest, and mother roots were slightly less toxic than fibrous roots. The stems and leaves were far less toxic than mother and fibrous roots. In addition, the analgesia and inflammatory tests showed the effects of the various tissues had no difference each other. These results provided a basis for developing new complementary and alternative treatments for rheumatoid arthritis patients. Simultaneously, the approach may also turn wastes into treasure and promote the development of circular economy. 关键词：ACONITUM carmichaelii Debx. New medical parts ALKALOIDS TOXICITY Efficacy

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Stems and leaves of Aconitum carmichaelii Debx.as potential herbal resources for treating rheumatoid arthritis: Chemical analysis,toxicity and activity evaluation

参考文献(34)

引证文献(11)

耦合文献(122)

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