Pioneering drugs for overactive bladder and detrusor overactivity: Ongoing research and future directions

查看全文 作　　者：Emilio [1]Sacco;Salvatore [1]Recupero;Riccardo [1]Bientinesi;Giuseppe [1]Palermo;Daniele D'[1]Agostino;Diego [2]Currò;Pierfrancesco [1]Bassi

机构地区：[1]Urologic Clinic, Department of Surgical Sciences, 'Agostino Gemelli' Hospital, Catholic University Medical School, 00168 Rome, Italy;[2]Institute of Pharmacology, Catholic University Medical School, 00168 Rome, Italy

出　　处：《World Journal of Obstetrics and Gynecology》索引2015年第4卷第2期,共16页

摘　　要：The ongoing research on pioneering drug candidates for the overactive bladder(OAB) aimed to overcome the limitations of currently licensed pharmacotherapies, such as antimuscarinics, β3-adrenergic agents, and botulinum neurotoxin, has been reviewed performing a systematic literature review and web search. The review covers the exploratory agents alternative to available medications for OAB and that may ultimately prove to be therapeutically useful in the future management of OAB patients based on preclinical and early clinical data. It emerges that many alternative pharmacological strategies have been discovered or are under investigation in disease-oriented studies. Several potential therapeutics are known for years but still find obstacles to pass the clinical stages of development, while other completely novel compounds, targeting new pharmacological targets, have been recently discovered and show potential to translate into clinical therapeutic agents for idiopathic and neurogenic OAB syndrome. The global scenario of investigational drugs for OAB gives promise for the development of innovative therapeutics that may ultimately prove effective as first, combined or second-line treatments within a realistic timescale of ten years. 关键词：膀胱药物治疗临床治疗剂疗效

相关文献

参考文献（198）
引证文献（3）
耦合文献（0）

参考文献(198)

引证文献(3)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Pioneering drugs for overactive bladder and detrusor overactivity: Ongoing research and future directions

参考文献(198)

引证文献(3)

用户提示