Baroreflex dysfunction in chronic kidney disease

查看全文 作　　者：Manpreet [1]Kaur;Dinu S [1]Chandran;Ashok Kumar [1]Jaryal;Dipankar [2]Bhowmik;Sanjay Kumar [2]Agarwal;Kishore Kumar [1]Deepak

机构地区：[1]Department of Physiology,All India Institute of Medical Sciences,New Delhi 110029,India;[2]Department of Nephrology,All India Institute of Medical Sciences,New Delhi 110029,India

出　　处：《World Journal of Nephrology》索引2016年第5卷第1期,共13页

摘　　要：Chronic kidney disease(CKD) patients have high cardiovascular mortality and morbidity. The presence of traditional and CKD related risk factors results in exaggerated vascular calcification in these patients. Vascular calcification is associated with reduced large arterial compliance and thus impaired baroreflex sensi-tivity(BRS) resulting in augmented blood pressure(BP) variability and hampered BP regulation. Baroreflex plays a vital role in short term regulation of BP. This review discusses the normal baroreflex physiology, methods to assess baroreflex function, its determinants along with the prognostic significance of assessing BRS in CKD patients, available literature on BRS in CKD patients and the probable patho-physiology of baroreflex dysfunction in CKD. 关键词：慢性肾脏疾病心血管治疗方法临床分析

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Baroreflex dysfunction in chronic kidney disease

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