Clustering of Cardiovascular Risk Factors and Diabetes: A Prospective Cohort Study on the Inner Mongolian Population in China

查看全文 作　　者：WANG Ting [1]Ting;LIN [1]Bo;CUI Wen [2]Xiu;ZHANG Ming [1]Zhi;ZHANG Yong [1]Hong;ZHANG Shao [1]Yan

机构地区：[1]Department of Epidemiology, School of Public Health andJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, China;[2]Harbin Center for Disease Control and Prevention, Harbin 150000, Heilongjiang, China

出　　处：《Biomedical and Environmental Sciences》索引2018年第31卷第10期,共8页

基　　金：supported by National Natural Science Foundation of China [Grant No.81773509],[Grant No.81102190];supported by a Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions,China 摘　　要：Objective To evaluate the effect of clustering of cardiovascular risk factors(CVRFs) on type 2 diabetes mellitus(T2 DM) incidence and identify some high predictive clusters in the Inner Mongolian population in China. Methods A total of 1,884 Mongolian individuals aged 20 years or above were followed up from 2002 to 2013 and included in the final analysis. We categorized the participants into two subgroups according to the study outcome event. A Cox proportional hazards model was used to evaluate the effect of clustering of CVRFs on the incidence of T2 DM. Areas under the curve were used to compare the effect of every cluster on T2 DM and identify those having higher predictive value. Results We found 203 persons with T2 DM. Subjects with incident T2 DM tended to be older, had a higher prevalence of drinking, had higher systolic and diastolic pressures; total cholesterol, triglyceride, low-density lipoprotein cholesterol, and C-reactive protein levels; waist circumference; body mass index; and heart rate and lower HDL-C level than did those without T2 DM. The multivariable adjusted hazard ratio(95% confidence interval) of T2 DM was calculated based on comparisons with subjects with 0 CVRFs; in participants with 2 and ≥ 3 factors, the adjusted hazard ratios were 2.257(1.448, 3.518) and 3.316(2.119, 5.188), respectively. Conclusion The clustering of CVRFs increased the risk of T2 DM. On the basis of fast heart rate, the cluster of abdominal obesity and other CVRFs had higher predictive value for T2 DM than the other three CVRF clusters. 关键词：风险因素糖尿病心血管聚类蒙古人口中国高级数据链路控制

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Clustering of Cardiovascular Risk Factors and Diabetes: A Prospective Cohort Study on the Inner Mongolian Population in China

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