MicroRNAs in heart and circulation during physical exercise

查看全文 作　　者：Lijun [1]Wang;Yicheng [1]Lv;Guoping [2]Li;Junjie [1]Xiao

机构地区：[1]Cardiac Regeneration and Ageing Lab,Institute of Cardiovascular Sciences,School of Life Science,Shanghai University,Shanghai 200444,China;[2]Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School,Boston,MA 02215,USA

出　　处：《Journal of Sport and Health Science》索引2018年第7卷第4期,共9页

基　　金：supported by grants from the National Natural Science Foundation of China(81722008,91639101,and81570362 to JX and 81800358 to LW);the Innovation Program of Shanghai Municipal Education Commission(2017-01-07-00-09-E00042 to JX);the Science and TechnologyCommission of Shanghai Municipality(17010500100 to JX);the development fund for Shanghai talents(to JX) 摘　　要：Exercise training is beneficial to the cardiovascular system. MicroRNAs(miRNAs, miRs) are a class of conserved non-coding RNAs and play a wide-ranging role in the regulation of eukaryotic gene expression. Exercise training alters the expression levels of large amounts of miRNAs in the heart. In addition, circulating miRNAs appear to be regulated by exercise training. In this review, we will summarize recent advances in the regulation of miRNAs during physical exercise intervention in various cardiovascular diseases, including pathologic cardiac hypertrophy, myocardial fibrosis, ischemia-reperfusion injury, myocardial infarction, and heart failure. The regulatory role of circulating miRNAs after exercise training was also reviewed. In conclusion, miRNAs might be a valuable target for treatment of cardiovascular diseases and have great potential as biomarkers for assessment of physical performance. 关键词：物理 MIRNAS 发行量心血管真核细胞上海大学训练非编码

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MicroRNAs in heart and circulation during physical exercise

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