Alterations of Monoamine Metabolites and Neurobehavioral Function in Lead-Exposed Workers

查看全文 作　　者：TANG HAI-WANG;LIANG YOU-XON;HU XIAO-HONG;AND YANG HONG-GUANG(Department of Occupational Health, Shanghai Medical University Shanghai 200032, China;Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China)(Please send req 出　　处：《Biomedical and Environmental Sciences》索引1995年第8卷第1期,共7页 摘　　要：Neurobehavioral and neurochemical effects of occupational lead exposure were invstigated by WHO Ncurobehavioral Core Test Battery (NCTB) testing and a serics of monoamine neurotransmitters and their metabolites analyzing in workers from lead smeltery and storage-battery manufacturing factory and matched controls. Indicators of lead exposure, the blood lead (PbB) and zinc protophorphyrin (ZPP) levels were found significantly higher in the expeed group compared with that of the controls (70.55μg/dL vs 3.6μg/dL; and 294.92 μg/dL vs 38.32μg/dL, respectively). Furthermore, elevated urinary homovanillic acid (HVA) and impairment of certain neurobehavioral performances were also found in the lead exposed wokers; the latter included attention/response speed, manual dexterity, perceptual-motor speed, visual perception/memory, and motor speed/steadiness. Positive or negative correlations were observed between certain parameters. Thus, homovanillic acid (HVA) is peitively correlated With PbB and ZPP; dopamine (DA) negatively correlated with Benton visual retention (BVR); and HVA negatively correlated with digit symbol (DSy), BVR, and pursuit aiming (PA). It is suggested that the alterations of dopamine and its metabolites HVA in urine associated with impairment of neurobehavioral function might be served as biomarkers of lead-induced neurotoxicity. 关 键 词：铅暴露工人 单胺代谢物 神经行为机能变化 神经化学变化