Compared efficacy of preservation solutions on the outcome of liver transplantation:Meta-analysis

查看全文 作　　者：Agnes Lilla [1]Szilágyi;Péter [2]Mátrai;Péter [3,4,5]Hegyi;Eszter [1]Tuboly;Daniella [1]Pécz;András [3]Garami;Margit [3]Solymár;Erika [3]Pétervári;Márta [3]Balaskó;Gábor [6]Veres;László [7]Czopf;Bastian [7]Wobbe;Dorottya [7]Szabó;Juliane [7]Wagner;Petra [1]Hartmann

机构地区：[1]Institute of Surgical Research,University of Szeged,Szeged H-6720,Hungary;[2]Institute of Bioanalysis,University of Pécs,Pécs H-7624,Hungary;[3]Institute for Translational Medicine and First Department of Medicine,University of Pécs,Pécs H-7624,Hungary;[4]MTA-SZTE Translational Gastroenterology Research Group,Szeged H-6720,Hungary;[5]János Szentágothai Research Center,University of Pécs,Pécs H-7624,Hungary;[6]1^st Department of Paediatrics,University of Semmelweis,Budapest H-1085,Hungary;[7]Department of Cardiology,1^st Department of Medicine,University of Pécs,Pécs H-7624,Hungary

出　　处：《World Journal of Gastroenterology》索引2018年第24卷第16期,共13页

基　　金：Supported by grants from the National Research Development and Innovation Office,NKFI K120232;Hungarian Science Research Fund,No.GINOP 2.3.2-15-2016-00015 and No.EFOP-3.6.2-16-2017-00006;New National Excellence Program of the Ministry of Human Capacities,No.UNKP-17-4 摘　　要：AIM To compare the effects of the four most commonly used preservation solutions on the outcome of liver transplantations.METHODS A systematic literature search was performed using MEDLINE, Scopus, EMBASE and the Cochrane Library databases up to January 31^(st), 2017. The inclusion criteria were comparative, randomized controlled trials(RCTs) for deceased donor liver(DDL) allografts with adult and pediatric donors using the gold standard University of Wisconsin(UW) solution or histidinetryptophan-ketoglutarate(HTK), Celsior(CS) and Institut Georges Lopez(IGL-1) solutions. Fifteen RCTs(1830 livers) were included; the primary outcomes were primary non-function(PNF) and one-year posttransplant graft survival(OGS-1). RESULTS All trials were homogenous with respect to donor and recipient characteristics. There was no statistical difference in the incidence of PNF with the use of UW, HTK, CS and IGL-1(RR = 0.02, 95%CI: 0.01-0.03, P = 0.356). Comparing OGS-1 also failed to reveal any difference between UW, HTK, CS and IGL-1(RR = 0.80, 95%CI: 0.80-0.80, P = 0.369). Two trials demonstrated higher PNF levels for UW in comparison with the HTK group, and individual studies described higher rates of biliary complications where HTK and CS were used compared to the UW and IGL-1 solutions. However, the meta-analysis of the data did not prove a statistically significant difference: the UW, CS, HTK and IGL-1 solutions were associated with nearly equivalent outcomes.CONCLUSION Alternative solutions for UW yield the same degree of safety and effectiveness for the preservation of DDLs, but further well-designed clinical trials are warranted. 关键词：Liver transplantation Preservation solution Primary non-function One-year post-transplant graft survival Systematic review META-ANALYSIS

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Compared efficacy of preservation solutions on the outcome of liver transplantation:Meta-analysis

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