Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation

查看全文 作　　者：Siddharth [1]Narayanan;Gopalakrishnan [1]Loganathan;Maheswaran [1]Dhanasekaran;William [1]Tucker;Ankit [1]Patel;Venugopal [2]Subhashree;SriPrakash [1]Mokshagundam;Michael G [1]Hughes;Stuart K [1]Williams;Appakalai N [1]Balamurugan

机构地区：[1]Clinical Islet Cell Laboratory, Center for Cellular Transplantation, Cardiovascular Innovation Institute, Department of Surgery, University of Louisville;[2]School of Biosciences and Technology,VIT University

出　　处：《World Journal of Transplantation》索引2017年第7卷第2期,共12页

摘　　要：The intra-islet microvasculature is a critical interface between the blood and islet endocrine cells governing a number of cellular and pathophysiological processes associated with the pancreatic tissue. A growing body of evidence indicates a strong functional and physical interdependency of β-cells with endothelial cells(ECs), the building blocks of islet microvasculature. Intra-islet ECs, actively regulate vascular permeability and appear to play a role in fine-tuning blood glucose sensing and regulation. These cells also tend to behave as 'guardians', controlling the expression and movement of a number of important immune mediators, thereby strongly contributing to the physiology of islets. This review will focus on the molecular signalling and crosstalk between the intra-islet ECs and β-cells and how their relationship can be a potential target for intervention strategies in islet pathology and islet transplantation. 关键词：ISLETS Endothelial cells ISLET cell transplantation BETA-CELLS MICROVASCULATURE PARACRINE signalling

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Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation

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