Role of copper transporters in platinum resistance

查看全文 作　　者：Deepak [1]Kilari;Elizabeth [2]Guancial;Eric S [2]Kim

机构地区：[1]Department of Medicine, Medical College of Wisconsin;[2]Departments of Medicine, University of Rochester Medical Center

出　　处：《World Journal of Clinical Oncology》索引2016年第7卷第1期,共8页

摘　　要：Platinum(Pt)-based antitumor agents are effective in the treatment of many solid malignancies. However, their efficacy is limited by toxicity and drug resistance. Reduced intracellular Pt accumulation has been consistently shown to correlate with resistance in tumors. Proteins involved in copper homeostasis have been identified as Pt transporters. In particular, copper transporter receptor 1(CTR1), the major copper influx transporter, has been shown to play a significant role in Pt resistance. Clinical studies demonstrated that expression of CTR1 correlated with intratumoral Pt concentration and outcomes following Pt-based therapy. Other CTRs such as CTR2, ATP7 A and ATP7 B, may also play a role in Pt resistance. Recent clinical studies attempting to modulate CTR1 to overcome Pt resistance may provide novel strategies. This review discusses the role of CTR1 as a potential predictive biomarker of Pt sensitivity and a therapeutic target for overcoming Pt resistance. 关键词：Resistance CISPLATIN COPPER TRANSPORTER RECEPTOR 1 COPPER TRANSPORTER COPPER TRANSPORTER RECEPTOR 2 ATP7A ATP7B

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Role of copper transporters in platinum resistance

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