Influence of mental stress on platelet bioactivity

查看全文 作　　者：Pia Koudouovoh-[1]Tripp;Barbara Sperner-[2]Unterweger

机构地区：[1]Clinic for Biological Psychiatry,Department of Psychiatry and Psychotherapy,Innsbruck Medical University,Anichstrasse 35,6020 Innsbruck,Austria;[2]Clinic for General Psychiatry,Department of Psychiatry and Psychotherapy,Innsbruck Medical University,Anichstrasse 35,6020 Innsbruck,Austria

出　　处：《World Journal of Psychiatry》索引2012年第2卷第6期,共14页

摘　　要：It is well established that various mental stress conditions contribute, or at least influence, underlying pathophysiological mechanisms in somatic, as well as in psychiatric disorders; blood platelets are supposed to represent a possible link in this respect. The anculeated platelets are the smallest corpuscular elements circulating in the human blood. They display different serotonergic markers which seem to reflect the central nervous serotonin metabolism. They are known as main effectors in haematological processes but recent research highlights their role in the innate and adaptive immune system. Platelets are containing a multitude of pro-inflammatory and immune-modulatory bioactive compounds in their granules and are expressing immune-competent surface markers. Research gives hint that platelets activation and reactivity is increased by mental stress. This leads to enhanced cross talk with the immune system via paracrine secretion, receptor interaction and formation of platelet leucocyteaggregates. Recently it has been demonstrated that the immune system can have a remarkable impact in the development of psychiatric disorders. Thereforeplatelets represent an interesting research area in psychiatry and their role as a possible biomarker has been investigated. We review the influence of mental stress on what is termed platelet bioactivity in this article, which subsumes the mainly immune-modulatory activity of platelets in healthy volunteers, elderly persons with chronic care-giving strain, patients with cardiovascular diseases who are prone to psychosocial stress, as well as in patients with posttraumatic stress disorder. Research data suggest that stress enhances platelet activity, reactivity and immune-modulatory capacities. 关键词：MENTAL STRESS CAREGIVING strain POSTTRAUMATIC STRESS disorder Cardiovascular disease SEROTONIN PLATELET activation PLATELET bioactivity

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Influence of mental stress on platelet bioactivity

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