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Low-grade central osteosarcoma of distal femur, resembling fibrous dysplasia

查看全文 作　　者：Haris S [1]Vasiliadis;Christina [1]Arnaoutoglou;Sotiris [1]Plakoutsis;Michalis [2]Doukas;Anna [2]Batistatou;Theodoros A [1]Xenakis 高影响力作者 机构地区：[1]Department of Orthopaedics, University Hospital of Ioannina;[2]Department of Pathology, University Hospital of Ioannina高影响力机构 出　　处：《World Journal of Orthopedics》索引2013年第4卷第4期,共6页高影响力期刊 摘　　要：We report a case of a 32 year-old male, admitted for a lytic lesion of the distal femur. One month after the first X-ray, clinical and imaging deterioration was evident. Open biopsy revealed fibrous dysplasia. Three months later, the lytic lesion had spread to the whole distal third of the femur reaching the articular cartilage. The malignant clinical and imaging features necessitated excision of the lesion and reconstruction with a custom-made total knee arthroplasty. Intraoperatively, no obvious soft tissue infiltration was evident. Nevertheless, an excision of the distal 15.5 cm of the femur including 3.0 cm of the surrounding muscles was finally performed. The histological examination of the excised specimen revealed central low-grade osteosarcoma. Based on the morphological features of the excised tumor, allied to the clinical findings, the diagnosis of low-grade central osteosarcoma was finally made although characters of a fibrous dysplasia were apparent. Central low-grade osteosarcoma is a rare, well-differentiated sub-type of osteosarcoma, with clinical, imaging, and histological features similar to benign tumours. Thus, initial misdiagnosis is usual with the condition commonly mistaken for fibrous dysplasia. Central low-grade osteosarcoma is usually treated with surgery alone, with rare cases of distal metastases. However, regional recurrence is quite frequent after close margin excision. 关 键 词：OSTEOSARCOMA Fibrous DYSPLASIA of bone Distal FEMUR Custom-made total knee ARTHROPLASTY TUMOUR
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