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Exogenous neural stem cell transplantation for cerebral ischemia

查看全文 作  者:Ling-Yi [1]Liao;Benson Wui-Man [2]Lau;Dalinda Isabel Sánchez-[2]Vidana;Qiang [1,2]Gao 高影响力作者 机构地区:[1]Department of Rehabilitation Medicine,West China Hospital,Sichuan University;[2]Department of Rehabilitation Sciences,The Hong Kong Polytechnic University高影响力机构 出  处:《Neural Regeneration Research》索引2019年第14卷第7期,共9页高影响力期刊 基  金:supported by the National Natural Science Foundation of China,No.0040205401797(to QG);the General Research Fund of China,No.15164216(to BWML) 摘  要:Cerebral ischemic injury is the main manifestation of stroke,and its incidence in stroke patients is 70–80%.Although ischemic stroke can be treated with tissue-type plasminogen activator,its time window of effectiveness is narrow.Therefore,the incidence of paralysis,hypoesthesia,aphasia,dysphagia,and cognitive impairment caused by cerebral ischemia is high.Nerve tissue regeneration can promote the recovery of the aforementioned dysfunction.Neural stem cells can participate in the reconstruction of the damaged nervous system and promote the recovery of nervous function during self-repair of damaged brain tissue.Neural stem cell transplantation for ischemic stroke has been a hot topic for more than 10 years.This review discusses the treatment of ischemic stroke with neural stem cells,as well as the mechanisms of their involvement in stroke treatment. 关 键 词:nerve regeneration stem cell therapy neural stem cells cell transplantation ischemic stroke cerebral ischemia NEUROPLASTICITY functional recovery neural regeneration
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