Full-term pregnancy in breast cancer survivor with fertility preservation: A case report and review of literature

查看全文 作　　者：Marta Garrido-[1]Marín;Pedro Maria [2]Argacha;Luís [3]Fernández;Florencia [4]Molfino;Fina Martínez-[5]Soler;Avelina [5]Tortosa;Pepita Gimenez-[1]Bonafé 机构地区：[1]Department of Physiological Sciences, Physiology Unit, Faculty of Medicine and Health Sciences, Bellvitge Campus, Universitat de Barcelona,IDIBELL, L’Hospitalet del Llobregat;[2]Hospital Universitari General de Catalunya;[3]Servicio de Oncología Médica, Consorcio Corporación Sanitaria Parc Taulí;[4]Instituto de Reproducción Cefer;[5]Department of Basic Nursing, Faculty of Medicine and Health Sciences, Universitat de Barcelona, IDIBELL, L’Hospitalet del Llobregat 出　　处：《World Journal of Clinical Cases》索引2019年第7卷第1期,共11页 基　　金：Supported by grants from the Instituto Carlos Ⅲ,Nos.PI11/01377 and ISCⅢ-RETICRD12/0036/0029;Government of Catalonia,No.2017SGR-1014 摘　　要：A 43-year-old woman with an associated history of gynecological pathology and breast cancer with only one cryopreserved embryo wished to be a mother.Several factors that influenced the success of the pregnancy in this case were analyzed. Favorable factors included: triple positive breast cancer [positive hormone receptors and positive human epidermal growth factor receptor 2],which is more hormosensitive and chemosensitive; absence of metastasis; correct endometrium preparation; and the patient's optimistic attitude and strict health habits. In contrast, the factors against success were: breast cancer; adjuvant breast cancer therapy gonadotoxicity; the age of the patient(> 40-year-old);endometriosis; ovarian cyst; hydrosalpinx; submucosal fibroids and the respective associated surgery done for the above-mentioned pathology(all resolved prior to the embryo transfer); and a low quantity of ovules(low ovarian reserve) after ovarian stimulation. This is a very special clinical case of a patient with theoretically low pregnancy success probability due to the consecutive accumulation of gynecological and oncological pathologies, who nonetheless became pregnant and delivered a full-term infant and was able to provide adequate breastfeeding. 关 键 词：Breast cancer FERTILITY preservation Gonadotoxicity PREGNANCY In VITRO fertilization HYDROSALPINX ENDOMETRIOSIS Case report