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Impact of main vessel calcification on procedural and clinical outcomes of bifurcation lesion undergoing provisional single-stenting intervention: a multicenter, prospective, observational study

查看全文 作　　者：Jing [1]BAI;Yan [1]YUE;Hong-Qi [2]FENG;Shu-Xin [2]HAO;Liang [3]PENG;Ming [1]ZHANG;Shaheena [4]Nazneen;Li-Feng [5]LIU;Zhe [6]TANG;Xiao-Lin [7]YU;Yu-Tao [8]XIE;Fu-Xiang [8]SHAN;Ming-Zhi [9]SHEN;Jiang-Tao [10]WANG;Xue-Hua [11]WAN;Yun-Dai [1]CHEN;Yu [1]WANG 高影响力作者 机构地区：[1]Department of Cardiology,Chinese PLA General Hospital,Beijing,China;[10]People's Hospital of Rongcheng,Shandong e,China;[11]Clifford Hospital,Guangdong,China;[2]Hengshui Cardiovescular Hospital,Hebei,China;[3]Fuwai Central China Cardiovascular Hospital,Henan,China;[4]Lab Aid Cardiac Hospital,Dhanmondi,Dhaka.Bangladesh;[5]Heart Center,Beijing Chaoyang Hospital,Capital Medical University,Beijing,China;[6]Emergency and Critical Care Center,Beijing Anzhen Hospital,Capital Medical University,Beijing Institute of Heart Lung and Blood Vessel Disease,Beijing,China;[7]People's Hospital of Xinjiang Uygur Autonomous Region,Xinjiang,China;[8]The People's Hospital in Jimusar,Xinjiang,China;[9]Hainan Branch of Chinese PLA General Hospital,Hainan,China高影响力机构 出　　处：《Journal of Geriatric Cardiology》索引2019年第16卷第2期,共8页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China(No.81670218-Mechanism study of CKIP-1 Regulating programmed necrosis induced by Myocardial Reperfusion Injury) 摘　　要：Background Few data on the combined effects of bifurcation and calcification on coronary artery disease(CAD)patients undergoing percutaneous coronary intervention(PCI)are available.This study evaluated the impact of main vessel(MV)calcification on the procedural and long-term outcomes in patients with CAD who underwent provisional single stent PCI.Methods This is a multicenter,prospective,observational study.Patients with bifurcation lesions were enrolled at 10 PCI centers in China from January 2015 to December 2017.Intravascular ultrasound or optical coherence tomography was performed in all patients to evaluate the MV calcification.Patients were treated with provisional single stent strategy using drug eluting stents and followed-up at 1 month,6 months and 12 months after discharge by telephone contact or outpatient visit.Repeated coronary imaging was performed within one year.We compared the procedural success rates in MV and in side branch(SB),and target lesion failure(TLF),defined as a composite of cardiac death,non-fatal myocardial infarction,definite or possible stent thrombosis and target lesion revascularization between patients with and without MV calcification.Results A total of 185 subjects were enrolled according to the inclusion and exclusion criteria of this study.MV calcification was detected in 119(64.3%,calcification group)and not found in 66(35.7%,non-calcification group)patients.The angiographic success rate of MV was 95.8%in the calcification group and 97.0%in the non-calcification group(P=0.91);the angiographic success rate of SB was 32.8%in the calcification group and 53.0%in the non-calcification group(P<0.05).During the one-year follow-up period,TLF occurred in 14(11.8%)patients in the calcification group and in 13(19.7%)in the non-calcification group{P=0.31).Multivariate regression analysis showed the same result(HR=1.23,95%CI:0.76-1.52,P=0.47).Calcification on group had higher recurrent angina than non-calcification group(13.51%vs.17.65%,P<0.05).Conclusions In patients with coronary bifurcation lesion treated with provisional one stent approach,calcification of MV is associated with lower SB procedural success rate,it could increase recurrence of angina;however,it was not associated with an increased risk of TLF. 关 键 词：Bifurcation lesion CORONARY artery disease CORONARY calciflcation Percutaneous CORONARY INTERVENTION
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