Clinical value of preoperative methylated septin 9 in Chinese colorectal cancer patients

查看全文 作　　者：Xue [1]Yang;Zhi-Jie [2]Xu;Xi [1]Chen;Shuang-Shuang [1]Zeng;Long [1]Qian;Jie [1]Wei;Mei [1]Peng;Xiang [1]Wang;Wan-Li [1]Liu;Hong-Ying [1]Ma;Zhi-Cheng [1]Gong;Yuan-Liang [1]Yan

机构地区：[1]Department of Pharmacy,Institute for Rational and Safe Medication Practices,National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University;[2]Department of Pathology,Xiangya Hospital,Central South University

出　　处：《World Journal of Gastroenterology》索引2019年第25卷第17期,共11页

基　　金：Supported by the National Natural Science Foundation of China,No.81803035,No.81703036,and No.81572946;the China Postdoctoral Science Foundation,No.2017M610510;the Youth Fund of Xiangya Hospital,No.2017Q17 摘　　要：BACKGROUND The methylated septin 9(mSEPT9) assay was the first blood-based test approved by the United States Food and Drug Administration as a colorectal screening test.However, the diagnostic and prognostic role of preoperative mSEPT9 for colorectal cancer(CRC) in Chinese patients is still unknown.AIM To improve the understanding of diagnostic and prognostic factors, serum m SEPT9 was detected in Chinese CRC patients.METHODS A retrospective analysis of 354 cases, of which 300 had CRC and 54 were normal,was performed in China. Patients' characteristics, treatments, and laboratory data, including age, the date of surgery, Union for International Cancer Control(UICC) stages, distant metastasis(M), and so on, were collected. Methylation levels of SEPT9 were quantified by quantitative, methylation-specific polymerase chain reaction before surgery. In addition, the effects of mSEPT9 on the occurrence and prognosis of 330 CRC cases from The Cancer Genome Atlas(TCGA) database were evaluated using bioinformatics analyses. Potential prognostic factors for overall survival(OS) and progression-free survival(PFS)were evaluated by Kaplan-Meier univariate analysis.RESULTSIn Chinese CRC patients, positive mSEPT9 was strongly associated with advanced UICC stages, deeper invasion by the primary tumor, and more distant metastasis. Methylation levels of SEPT9 were stage-dependent and showed a stepwise increase in UICC stages(I–IV), primary tumor categories(T1–T4),regional node categories(N0–N2), and distant metastasis categories(M0–M1).The patients with positive mSEPT9 showed a tendency toward lower PFS. After analyzing TCGA clinical data, the high mSEPT9 group was found to be obviously correlated only with more distant metastasis. The patients with high mSEPT9 levels showed a tendency toward lower OS. Besides, nine meaningful mSEPT9 sites were found to provide guidance for the follow-up studies.CONCLUSION MSEPT9 analysis may add valuable information to current tumor staging. Serum m SEPT9 in Chinese CRC patients appears to offer promising novel prognostic markers and might be considered for monitoring CRC recurrence. 关键词：Methylated SEPTIN 9 Methylated COLORECTAL cancer Diagnosis PROGNOSIS

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Clinical value of preoperative methylated septin 9 in Chinese colorectal cancer patients

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