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Kidney-Qi deficiency diagnosed by Deng's diagnosis standard was not correlated with aging based on clinical observation of 90 participants

查看全文 作　　者：Zhao [1]Zhengxiao;Liu [1,2,3]Lumei;Tang [1,2,3]Zihui;Mohammadtursun [1,2,3]Nabijan;Lu [1,2,3]Linwei;Li [1,2,3]Mihui;Lü [1,2,3]Yibao;Mo [1,2,3]Shuming;Ma [4]Wenjuan;Wang [5]Meng;Wei [1,2,3]Ying;Gong [1]Weiyi;Dong [1]Jingcheng 高影响力作者 机构地区：[1]Department of Integrative Medicine, Huashan Hospital, Fudan University;[2]Institute of Theories and Application, Institutes of Integrative Medicine of Fudan University;[3]Department of Integrative Medicine, College of Clinical Medicine, Fudan University;[4]Department of Dermatology, Huashan Hospital, Fudan University;[5]Physical Examination Center, Huashan Hospital, Fudan University高影响力机构 出　　处：《Journal of Traditional Chinese Medicine》索引2019年第39卷第2期,共8页高影响力期刊 基　　金：Supported by Shanghai Municipal Commission of Health and Family Planning Project:Preliminary Study on the Construction of Asthma Integrative Medicine Management Platform based on Smart Devices and Mobile Internet(No.ZYKC201602001) 摘　　要：OBJECTIVE: To verify the Traditional Chinese Medicine(TCM) theory that kidney-Qi deficiency(KQD)is considered to be the main cause of aging using cross-sectional study.METHODS: Demographic and lifestyle characteristics of 90 healthy participants were collected with a self-administered questionnaire. KQD syndrome was diagnosed according to Deng's diagnosis standard. Creatinine-adjusted urinary 8-hydroxy-2'-deoxyguanosine(8-OH-dG) and 8-isomeric-prostaglandin2α(8-iso-PGF2α), salivary advanced oxidation protein products(AOPPs), malondialdehyde(MDA) and dehydroepiandrosterone-sulfate(DHEA-S) were selected as aging markers and measured using enzyme-linked immunosorbent assay.RESULTS: No significant differences were observed in participant characteristics between the KQD group and non-KQD(NKQD) group(P > 0.05). Levels of 8-OH-dG, 8-iso-PGF2α, AOPPs, and MDA increased with age, except for a slight decrease in8-OH-dG in the older group. The increase in8-iso-PGF2α was significant(P < 0.05). DHEA-S significantly decreased with increasing age(P < 0.01).8-OH-dG levels were higher in the KQD group compared with the NKQD group. Levels of urinary8-iso-PGF2α, salivary AOPPs, and MDA in the KQD group were lower than in the NKQD group. Salivary DHEA-S was higher in the KQD group compared with the NKQD group. However, differences between KQD group and NKQD group were not significant.CONCLUSION: The current results suggested that KQD syndrome, as diagnosed by Deng's standard,does not underlie the aging phenotype. 关 键 词：AGING Kidney-Qi deficiency Advanced oxidation protein products MALONDIALDEHYDE DEHYDROEPIANDROSTERONE sulfate Cross-sectional studies
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