TCF7L1 indicates prognosis and promotes proliferation through activation of Keap1/NRF2 in gastric cancer

查看全文 作　　者：Beili [1]Zhang;Jugang [1]Wu;Yantao [1]Cai;Meng [1]Luo;Bing [1]Wang;Yan [1]Gu 机构地区：[1]Department of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China 出　　处：《Acta Biochimica et Biophysica Sinica》索引2019年第51卷第4期,共11页 摘　　要：Gastric can cer is one of the most comm on cancers worldwide and is the third leadi ng cause of cancer-related deaths globally. Although significant progress has been made in the diagnosis and treatment for the cancer, less improvement has been made in overall survival rate. Thus, there is an urgent need for a better understanding of the biological aspects of the cancer. The transcription factor transcription factor 7-like 1 (TCF7L1) is an embryonic stem cell signature gene that is upregulated in multiple aggressive cancer types, but its role in gastric cancer has seldom been discussed. In the present study, by using the Cancer Genome Atlas dataset analysis, we demonstrated that patients with higher expression of TCF7L1 could be used to reflect prognosis. An examination of the mechanisms demonstrated that TCF7L1 could positively regulate antioxidant response in gastric cancer cells by positively regulating Keap1/NRF2 [Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2] pathway. Collectively, our data demonstrated that TCF7L1 is a novel marker for predicting overall survival of gastric cancer and provided the possible underlying molecular mechanism. 关 键 词：GASTRIC cancer TCF7L1 ANTIOXIDANT response Keapl NRF2