Hepatocellular carcinoma: Therapeutic advances in signaling,epigenetic and immune targets

查看全文 作　　者：Daniel [1]Neureiter;Sebastian [2]Stintzing;Tobias [3]Kiesslich;Matthias [4,5]Ocker

机构地区：[1]Institute of Pathology,Cancer Cluster Salzburg,Paracelsus Medical University/Salzburger Landeskliniken(SALK),Salzburg 5020,Austria;[2]Medical Department,Division of Oncology and Hematology,Campus CharitéMitte,CharitéUniversity Medicine Berlin,Berlin 10117,Germany;[3]Department of Internal Medicine I,Paracelsus Medical University/Salzburger Landeskliniken(SALK)and Institute of Physiology and Pathophysiology,Paracelsus Medical University,Salzburg 5020,Austria;[4]Translational Medicine Oncology,Bayer AG,Berlin 13353,Germany;[5]CharitéUniversity Medicine Berlin,Berlin 10117,Germany

出　　处：《World Journal of Gastroenterology》索引2019年第25卷第25期,共15页

摘　　要：Hepatocellular carcinoma(HCC)remains a global medical burden with rising incidence due to chronic viral hepatitis and non-alcoholic fatty liver diseases.Treatment of advanced disease stages is still unsatisfying.Besides first and second generation tyrosine kinase inhibitors,immune checkpoint inhibitors have become central for the treatment of HCC.New modalities like epigenetic therapy using histone deacetylase inhibitors(HDACi)and cell therapy approaches with chimeric antigen receptor T cells(CAR-T cells)are currently under investigation in clinical trials.Development of such novel drugs is closely linked to the availability and improvement of novel preclinical and animal models and the identification of predictive biomarkers.The current status of treatment options for advanced HCC,emerging novel therapeutic approaches and different preclinical models for HCC drug discovery and development are reviewed here. 关键词：Liver cancer Immunotherapy CHECKPOINT inhibitors Targeted therapy Mouse model Biomarker Next-generation sequencing Non-alcoholic STEATOHEPATITIS FIBROSIS Clinical trial

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Hepatocellular carcinoma: Therapeutic advances in signaling,epigenetic and immune targets

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