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Predictive values of multidetector-row computed tomography combined with serum tumor biomarkers in preoperative lymph node metastasis of gastric cancer

查看全文 作　　者：Huihui [1]Bai;Jingyu [1]Deng;Nannan [1]Zhang;Huifang [1]Liu;Wenting [1]He;Jinyuan [1]Liu;Han [1]Liang 高影响力作者 机构地区：[1]Department of Gastric Cancer, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer高影响力机构 出　　处：《Chinese Journal of Cancer Research》索引2019年第31卷第3期,共10页高影响力期刊 基　　金：supported in part by grants from the Programs of National Natural Science Foundation of China (No. 81572372);National Key Research and Development Program “major chronic non-infectious disease research” (No. 2016YFC1303202);National Key Research and Development Program “precision medicine research” (No. 2017YFC0908304) 摘　　要：Objective: Multidetector-row computed tomography(MDCT) and serum tumor biomarkers are commonly used to evaluate the preoperative lymph node metastasis and the clinical staging of gastric cancer(GC). This study intends to evaluate the clinical predictive value of MDCT and serum tumor biomarkers in lymph node metastasis of GC.Methods: The clinicopathologic data of 445 GC patients who underwent radical gastrectomy were retrospectively analyzed to evaluate the diagnostic value of MDCT and serum tumor biomarkers in lymph node metastatic staging of GC before surgery.Results: With the multinomial logistic regression analysis, the independent relative factors of lymph node metastasis of GC were identified as tumor size, depth of tumor invasion, vessel invasion, vascular embolus, and soft tissue invasion. The optimal critical value of the short diameter of lymph nodes detected by MDCT scanning for evaluation of preoperative lymph node metastasis was 6.0 mm, with 75.7% as predictive accuracy of lymph node metastasis compared to the postoperative pathological results of GC patients. In addition, the critical value of the short diameter of lymph nodes combined with serum tumor biomarkers [including carbohydrate antigen(CA)-724 and CA-199] could show an enhancement of predictive sensitivity of lymph node metastasis(up to 89.3%) before surgery.Conclusions: MDCT combined with serum tumor biomarkers should be adopted to improve preoperative sensitivity and accuracy of lymph node metastasis for GC patients. 关 键 词：GASTRIC cancer MDCT SERUM TUMOR biomarkers PREOPERATIVE
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