Defective autophagy and Alzheimer’s disease: is calcium the key?

查看全文 作　　者：Riccardo [1]Filadi;Paola [1]Pizzo

机构地区：[1]Department of Biomedical Sciences, University of Padua and Neuroscience Institute-Italian National Research Council (CNR)

出　　处：《Neural Regeneration Research》索引2019年第14卷第12期,共2页

基　　金：supported by Italian Ministry of University and Scientific Research,the University of Padua(to PP);the EU Joint Programme-Neurodegenerative Disease Research(CeBioND)(to PP);UNIPD Funds for Research Equipment-2015 摘　　要：Presenilins and autophagy: Presenilin 1 (PS1) and presenilin 2 (PS2) are homologous, multi-pass transmembrane proteins endowed with pleiotropic functions, ranging from the regulation of membrane trafficking to cell differentiation. Their catalytic activity within the γ-secretase complex, an aspartyl-protease responsible for the intramembrane cleavage of several different type I transmembrane proteins, has been intensively studied in the context of Alzheimer’s disease (AD). Indeed, tens of autosomal dominant mutations in the PSEN1 and PSEN2 genes (encoding PS1 and PS2, respectively) have been associated with the rare familial forms of AD (FAD). 关键词：ALZHEIMER IS cell TENS has PS1 PS2

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Defective autophagy and Alzheimer’s disease: is calcium the key?

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