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Boosting the photodynamic therapy efficiency with a mitochondria-targeted nanophotosensitizer

查看全文 作　　者：Limin [1]Yang;Peng [1]Gao;Yuanlei [1]Huang;Xiao [1]Lu;Qian [1]Chang;Wei [1]Pan;Na [1]Li;Bo [1]Tang 高影响力作者 机构地区：[1]College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University高影响力机构 出　　处：《Chinese Chemical Letters》索引2019年第30卷第6期,共4页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China(Nos. 21535004, 91753111, 21874086, 21775094, 21505087, 21390411);the Key Research and Development Program of Shandong Province(No. 2018YFJH0502) 摘　　要：Photodynamic therapy (PDT) is an attractive clinical technique for cancer treatment. However, the poor solubility and weak cellular internalization of the molecule-photosensitizers, as well as the exceedingly short lifetime and limited diffusion distance of the generated reactive oxygen species (ROS) in cytoplasm directly restricted the therapeutic efficiency of conventional PDT. In this study, we proposed a facile strategy for improving PDT of cancer based on a mitochondria-targeted nanophotosensitizer. The molecule-photosensitizer chlorin e6 was covalently attached on the internal and external surfaces of the mesoporous silica nanoparticles. Then, the triphenylphosphonium was anchored on the nanoparticles for selectively targeting mitochondria. When irradiated with laser, the nanophotosensitizer can generate a large amount of ROS in mitochondria, thus causing the mitochondrial dysfunction and irreversible cell apoptosis. In vitro and in vivo studies demonstrated that the nanophotosensitizer could boost the treatment efficiency against cancer cells and xenograft tumor models. 关 键 词：MITOCHONDRIA Nanophotosensitizer Photodynamic therapy Reactive oxygen species Enhanced treatment EFFICIENCY
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