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Effect of herb-partitioned moxibustion on dopamine levels and dopamine receptor 1 expression in the colon and central nervous system in rats with Crohn’s disease

查看全文 作　　者：Lu [1]Yuan;Zheng [2]Handan;Lü [2]Tingting;Ma [2]Zhe;Wu [2]Huangan;Xu [3]Manwen;Weng [2]Zhijun;Feng [4]Hui;Zhang [2]Fang;Ding [1]Guanghong;Wu [2]Luyi;Liu [2]Huirong 高影响力作者 机构地区：[1]Department of Mechanics and Engineering Science, Fudan University, Shanghai 200433,China;[2]Shanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China;[3]Department of Acupuncture and Moxibustion,Huashan Hospital, Shanghai 200040, China;[4]Department of Acupuncture and Moxibustion and Tuina, Guanghua Hospital, Shanghai 200052, China高影响力机构 出　　处：《Journal of Traditional Chinese Medicine》索引2019年第39卷第3期,共8页高影响力期刊 基　　金：Supported by the National Basic Research Program of China(973 Program,No.2015CB554501);Program of National Natural Science Foundation of China(No.81574079);Program for outstanding medical academic leader(2015,No.80);Shuguang Program of Shanghai Education Commission(No.14SG39);Shanghai Rising-Star Program(No.16QA1403400) 摘　　要：OBJECTIVE:To observe the effect of herb-partitioned moxibustion at the Tianshu (ST 25) and Qihai (CV 6) acupoints in rats with Crohn's disease,and explore the underlying mechanism from dopamine (DA) and dopamine receptor 1 (D1 R) in the colon,spinal dorsal horn and hypothalamus.METHODS:The rats were randomly divided into the normal,model (CD),herb-partitioned moxibustion (Mox) and mesalazine (Mesa) groups.Damage in the colons was scored and observed by hematoxylin and eosin staining.DA and D1R protein expression in the colonic mucosa were detected by immunohistochemistry.The concentrations of DA and D1R in the spinal dorsal horn and hypothalamus were measured by enzyme-linked immunosorbent assay,and D1R mRNA expression was evaluated by quantitative real-time polymerase chain reaction.RESULTS:In the colon,compared with the normal group,DA,D1 R protein expressions and D1 R mRNA expression were significantly higher in the model group,while decreased in the Mox group and the Mesa group.In the spinal dorsal horn and hypothalamus,compared with the normal group,the concentrations of DA and D1 R,and the D1R mRNA expressions were significantly higher in the model group,and decreased in the Mox group and the Mesa group.CONCLUSION:Herb-partitioned moxibustion at the Tianshu (ST 25) and Qihai (CV 6) acupoints relieved ulceration in CD rats,the underlying mechanism maybe relative with the regulation of DA and D1R in the colon,spinal dorsal horn and hypothalamus by moxibustion. 关 键 词：Crohn disease DOPAMINE Receptors,dopamine Neuropeptides POINT ST25 (Tianshu) POINT CV6 (Qihai) Herb-partitioned MOXIBUSTION
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