Fabrication and Characterization of Nanopillar-Like HA Coating on Porous Ti6Al4V Scaffold by a Combination of Alkali–Acid-Heat and Hydrothermal Treatments

查看全文 作　　者：Jun-Lei [1]Li;Shuai [1]Wang;Fang [1]Cao;Xiao [2]Lin;Xiao-Wei [1]Wei;Zhen-Hua [1]Zhao;Xiao-Jie [1]Dou;Wei-Ting [1]Yu;Ke [3]Yang;De-Wei [1]Zhao

机构地区：[1]Department of Orthopaedics,Affiliated Zhongshan Hospital of Dalian University,Dalian 116001,China;[2]Orthopaedic Institute,Medical College,Soochow University,Suzhou 215006,China;[3]Institute of Metal Research,Chinese Academy of Sciences,Shenyang 110016,China

出　　处：《Acta Metallurgica Sinica(English Letters)》索引2019年第32卷第9期,共14页

基　　金：financially supported by the National Basic Research Program of China (Grant No. 2016YFC1102000);the National Natural Science Foundation of China (Grant Nos. 81672139 and 81702129);the China Postdoctoral Science Foundation (No. 171479);the Doctor Initial Foundation of Liaoning Province (No. 20170520017);the Affiliated Zhongshan Hospital of Dalian University (No. DLDXZSYY-DK201701) 摘　　要：Porous titanium scaffold with suitable porous architecture exhibits enormous potentials for bone defect repairs.However,insufficient osteointegration and osteoinduction still remain to open as one of the major problems to achieve satisfactory therapeutic effect.To solve this problem,many studies have been carried out to improve the bioactivity of porous titanium scaff old by surface modifications.In this study,porous Ti6Al4V scaff olds were fabricated using additive manufacturing technique.Porous architectures were built up based on a diamond pore structure unit.Alkali–acid-heat(AH)treatment was applied to create a TiO2 layer on the porous Ti6Al4V scaff old(AH-porous Ti6Al4V).Subsequently,a hydrothermal treatment was employed to enable the formation of HA coating with nanopillar-like morphology on the alkali–acid-heat-treated surface(HT/AH-porous Ti6Al4V).The effects of surface modifications on apatite-forming ability,protein adsorption,cell attachment,cell proliferation and osteogenic gene expression were studied using apatite-forming ability test,protein adsorption assay and in vitro cell culture assay.It was found that the HT/AH-porous Ti6Al4V exhibited the highest apatite formation ability and best affinity to fibronectin and vitronectin.In vitro studies indicated that the mesenchymal stem cells(MSCs)cultured on the HT/AH-porous Ti6Al4V presented improved adhesion and differentiation compared with the porous Ti6Al4V and AH-porous Ti6Al4V. 关键词：Additive manufacturing BIOMATERIALS POROUS titanium SCAFFOLD HA coating

相关文献

参考文献（64）
引证文献（2）
耦合文献（1）

参考文献(64)

引证文献(2)

耦合文献(1)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Fabrication and Characterization of Nanopillar-Like HA Coating on Porous Ti6Al4V Scaffold by a Combination of Alkali–Acid-Heat and Hydrothermal Treatments

参考文献(64)

引证文献(2)

耦合文献(1)

用户提示