Overview of studies of the vitamin D/vitamin D receptor system in the development of non-alcoholic fatty liver disease

查看全文 作　　者：Flavia Agata [1]Cimini;Ilaria [1]Barchetta;Simone [2]Carotti;Sergio [2]Morini;Maria Gisella [1]Cavallo

机构地区：[1]Department of Experimental Medicine,Sapienza University of Rome,Rome I-00161,Italy;[2]Department of Medicine and Surgery,Laboratory of Microscopic and Ultrastructural Anatomy,University Campus Bio-Medico of Rome,Rome I-00128,Italy

出　　处：《World Journal of Gastrointestinal Pathophysiology》索引2019年第10卷第2期,共6页

摘　　要：Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease in the world.NAFLD is known to be associated with obesity,type 2 diabetes,metabolic syndrome and increased cardiovascular events:for these reasons,it is becoming a global public health problem and represents an important challenge in terms of prevention and treatment.The mechanisms behind the pathogenesis of NAFLD are multiple and have not yet been completely unraveled;consequently,at moment there are not effective treatments.In the past few years a large body of evidence has been assembled that attributes an important role in hepatic aberrant fat accumulation,inflammation and fibrosis,to the vitamin D/vitamin D receptor(VD/VDR)axis,showing a strong association between hypovitaminosis D and the diagnosis of NAFLD.However,the data currently available,including clinical trials with VD supplementation,still provides a contrasting picture.The purpose of this editorial is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to VD/VDR.Based on recent data from literature,we focused in particular on the hypothesis that VDR itself,independently from its traditional ligand VD,may have a crucial function in promoting hepatic fat accumulation.This might also offer new possibilities for future innovative therapeutic approaches in the management of NAFLD. 关键词：VITAMIN D VITAMIN D RECEPTOR Non-alcoholic FATTY liver disease Type 2 DIABETES

相关文献

参考文献（57）
引证文献（5）
耦合文献（0）

参考文献(57)

引证文献(5)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Overview of studies of the vitamin D/vitamin D receptor system in the development of non-alcoholic fatty liver disease

参考文献(57)

引证文献(5)

用户提示