Bone marrow microenvironment: The guardian of leukemia stem cells

查看全文 作　　者：Mohammad [1]Houshmand;Teresa Mortera [2]Blanco;Paola [1]Circosta;Narjes [3]Yazdi;Alireza [4]Kazemi;Giuseppe [1]Saglio;Mahin Nikougoftar [2,5]Zarif

机构地区：[1]Department of Clinical and Biological Sciences, University of Turin, Turin 10126, Italy;[2]Center for Hematology and Regenerative Medicine, Karolinska Institutet, Department of Medicine, Karolinska University Hospital Huddinge, Stockholm 14183, Sweden;[3]Department of Molecular Genetics, Tehran Medical Branch, Islamic Azad University, Tehran 1916893813, Iran;[4]Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran;[5]Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran 146651157, Iran

出　　处：《World Journal of Stem Cells》索引2019年第11卷第8期,共15页

摘　　要：Bone marrow microenvironment (BMM) is the main sanctuary of leukemic stem cells (LSCs) and protects these cells against conventional therapies. However, it may open up an opportunity to target LSCs by breaking the close connection between LSCs and the BMM. The elimination of LSCs is of high importance, since they follow cancer stem cell theory as a part of this population. Based on cancer stem cell theory, a cell with stem cell-like features stands at the apex of the hierarchy and produces a heterogeneous population and governs the disease. Secretion of cytokines, chemokines, and extracellular vesicles, whether through autocrine or paracrine mechanisms by activation of downstream signaling pathways in LSCs, favors their persistence and makes the BMM less hospitable for normal stem cells. While all details about the interactions of the BMM and LSCs remain to be elucidated, some clinical trials have been designed to limit these reciprocal interactions to cure leukemia more effectively. In this review, we focus on chronic myeloid leukemia and acute myeloid leukemia LSCs and their milieu in the bone marrow, how to segregate them from the normal compartment, and finally the possible ways to eliminate these cells. 关键词：BONE MARROW MICROENVIRONMENT BONE MARROW NICHE Leukemic stem cell Chronic MYELOID LEUKEMIA Acute MYELOID LEUKEMIA Target therapy

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Bone marrow microenvironment: The guardian of leukemia stem cells

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