Genetic variants in the PLS3 gene are associated with osteoporotic fractures in postmenopausal Chinese women

查看全文 作　　者：Chong [1]Shao;Yi-wen [2]Wang;Jin-wei [1]He;Wen-zhen [1]Fu;Chun [1]Wang;Zhen-lin [1]Zhang

机构地区：[1]Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China;[2]Georgetown University, Washington, DC, USA

出　　处：《Acta Pharmacologica Sinica》索引2019年第40卷第9期,共7页

基　　金：This study was supported by the National Basic Research Program of China (973 Program)(2014CB942903);the National Natural Science Foundation of China (NSFC)(81370978 to Z.L.Zhang and 81270964 to CW);The study was also supported by the Shanghai Leading Talents Award (051 to Z.L.Zhang);Science and Technology Commission of Shanghai Municipality (14JC1405000 to ZLZ);Chongqing Research Program of Basic Research and Frontier Technology (CSCT2013jcyjC00009 to ZLZ);the Frontier Technology Joint Research Program of Shanghai Municipal Hospitals (SHDC12013115 to ZLZ). 摘　　要：Plastin 3 (PLS3) has been identified as a candidate gene for bone fragility in the Rotterdam study (RS) population. So far, however, whether PLS3 polymorphisms are genetic risk factors for osteoporosis in Asian population remains unclear. In order to investigate the association between genetic variants in PLS3 and the risk of fragility fracture and/or bone mineral density (BMD) in postmenopausal Chinese women, we conducted a case-control association study. A total of 1083 postmenopausal patients with osteoporotic fractures and 2578 unrelated non-fracture controls in Shanghai were enrolled. Seven SNPs, including six tagSNPs in PLS3 and one identified genetic risk factor (rs140121121) for osteoporosis in the RS population, were genotyped in all the participants. BMD at lumbar spine and hip sites were measured in 2578 controls. Association between SNPs and the risk of osteoporotic fractures and/or BMD were analyzed. The GC genotype of rs757124 and AC genotype of rs10521693 were associated with lumbar vertebral fracture (P=0.020 and 0.046, respectively). The association between tagSNPs and BMD were analyzed only in 2546 controls to avoid biased conclusion. rs757124 was significantly associated with BMD at lumbar spine and hip sites. GG genotype had the highest BMD at lumbar spine (L1-4), while CC genotype had the highest BMD at hip sites. Our results suggest that polymorphisms in PLS3 are genetic loci for osteoporosis in postmenopausal Chinese women. 关键词：Plastin 3 POLYMORPHISMS OSTEOPOROSIS fracture BONE MINERAL density POSTMENOPAUSAL Chinese women

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Genetic variants in the PLS3 gene are associated with osteoporotic fractures in postmenopausal Chinese women

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