Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin

查看全文 作　　者：Yiqiong [1,8]Liu;Yunong [7]Sun;Xiaoyan [2]Zhao;Ji-Young [3]Kim;Lu [4]Luo;Qian [4]Wang;Xiaolu [6]Meng;Yonghui [6]Li;Nan [6]Sui;Zhou-Feng [3]Chen;Chuxiong [2]Pan;Liang [4,5]Li;Yan [1,8]Zhang

机构地区：[1]State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871, China;[2]Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China;[3]Department of Anesthesiology, Department of Psychiatry, Department of Developmental Biology, Center for the Study of Itch, Washington University School of Medicine, Saint Louis, MO 63110, USA;[4]School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing 100871, China;[5]Beijing Institute for Brain Disorders, Beijing 100069, China;[6]Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China;[7]Hendrix College, Conway, AR 72032, USA;[8]PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China

出　　处：《Neuroscience Bulletin》索引2019年第35卷第5期,共12页

基　　金：supported by the National Natural Science Foundation of China (81425009, 31630028, 91632305, 30950030, 31170988, and 81671044);the National Basic Research Development Program (973 Program) of China (2009CB522002) 摘　　要：Isolation rearing(IR) enhances aggressive behavior, and the central serotonin(5-hydroxytryptamine,5-HT) system has been linked to IR-induced aggression.However, whether the alteration of central serotonin is the cause or consequence of enhanced aggression is still unknown. In the present study, using mice deficient in central serotonin Tph2-/-and Lmx1 b-/-, we examined the association between central serotonin and aggression with or without social isolation. We demonstrated that central serotonergic neurons are critical for the enhanced aggression after IR. 5-HT depletion in wild-type mice increased aggression. On the other hand, application of 5-HT in Lmx1 b-/-mice inhibited the enhancement of aggression under social isolation conditions. Dopamine was downregulated in Lmx1 b-/-mice. Similar to 5-HT, L-DOPA decreased aggression in Lmx1 b-/-mice. Our results linkthe serotoninergic system directly to aggression and this may have clinical implications for aggression-related human conditions. 关键词：5-HT AGGRESSION SOCIAL ISOLATION DOPAMINE Lmx1b

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Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin

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