Rock paper scissors: CRISPR/Cas9-mediated interference with geminiviruses in plants

查看全文 作　　者：Xiuling [1]Yang;Huanbin [1]Zhou;Xueping [1,2]Zhou

机构地区：[1]State Key Laboratory for Biology of Plant Diseases and Insect Pests,Institute of Plant Protection,Chinese Academy of Agricultural Sciences, Beijing 100193,China;[2]State Key Laboratory of Rice Biology,Institute of Biotechnology,Zhejiang University,Hangzhou 310058,China

出　　处：《Science China(Life Sciences)》索引2019年第62卷第10期,共3页

摘　　要：Geminiviruses are a group of circular single-stranded DNA viruses that constitute the largest family of plant viruses. Many diseases resulting from geminivirus infections, such as maize streak disease, cassava mosaic disease, tomato yellow leaf curl disease and cotton leaf curl diseases, cause significant problems in terms of economic losses, posing a serious threat to global crop productivity (Hanley-Bowdoin et al., 2013;Yang et al., 2019). As obligate intracellular parasites, geminiviruses cannot be controlled chemically. Conventional strategies to control geminiviruses rely heavily on the application of pesticides to limit insect vector populations, but it causes environmental concerns. To date, developing novel crop germplasms with durable disease resistance to geminiviruses is still the best strategy to manage viral infections due to its environmental friendliness. However, traditional breeding programs are time-intensive and labor-consuming processes, and transgene-based modern approaches by overexpressing the geminiviral proteins (e.g., the truncated form of the replication initiator protein) failed to confer resistance to geminiviruses due to activated virusinduced transgene silencing. 关键词：MOSAIC DISEASE INSECT vector DISEASE resistance

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Rock paper scissors: CRISPR/Cas9-mediated interference with geminiviruses in plants

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