The Induction of Liver Microsomal Cytochrome P450 by Glycyrrhiza uralensis and Glycyrrhetinic acid in Mice

查看全文 作　　者：HU WEN-YU;LI YA-WEI;HOU YAN-NING;HE KAN;(Department of Pharmacology, Instiute of Materia Medica, Chinese Academy of Medical Scicnces & Beijing Union Medical College, Beijing 100050, China) CHEN JIE-FU ;(Yang-Ming Medical University, Taipei);BUT PAUL PU

出　　处：《Biomedical and Environmental Sciences》索引1999年第12卷第1期,共5页

摘　　要：The effect of Glycyrrhiza uralensis Fisch (GRZ) aqueous extract and one of its active principles Glycyrrhetinic acid (GRT) on hepatic cytochrome P450 in mice were investigated. Oral administration of GRZ at 10g/kg/d or GRT at 50 mg/kg/d for 7 days was foulld to increase the P450 contents up to 4.6 fold compared with the controls. The activities of aryl hydrocarbon hydroxylase (AHH,3. 1 and 3. 3 fold), aminopyrine N-demethylase (ADM, 4. 2 and 3. 2 folds), and 7-ethoxycumarin O-deethylase (ECOD, 2. 8 and 2. 5 fold) were also shown to be increased. Westem blot analysis showed that the subtypes of P450 isoforms induced selectively by GRZ and GRT included CYP1A1 (1. 8 and 1. 5 fold over that of the control, respectively), CYP2B1 (both 1.3 fold), and CYP2C11(3 .2 and 3 .0 fold). Moreover, significant positive correlation between the P450 content or the isoforms and the corresponding enzyme activities mentioned above was observed. 关键词：马拉尔苷草甘草次酸大鼠肝脏微粒体诱导作用细胞色素P450

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The Induction of Liver Microsomal Cytochrome P450 by Glycyrrhiza uralensis and Glycyrrhetinic acid in Mice

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