Additive manufacturing of bone scaffolds

查看全文 作　　者：Youwen [1,2]Yang;Guoyong [1]Wang;Huixin [3]Liang;Chengde [2]Gao;Shuping [4]Peng;Lida [3]Shen;Cijun [1,2,5]Shuai

机构地区：[1]Jiangxi University of Science and Technology,Nanchang 330013,China;[2]State Key Laboratory of High Performance Complex Manufacturing,Central South University,Changsha 410083,China;[3]College of Mechanical and Electrical Engineering,Nanjing University of Aeronautics and Astronautics,210016 Nanjing,China;[4]Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine,Central South University,Changsha 410013,China;[5]Key Laboratory of Organ Injury,Aging and Regenerative Medicine of Hunan Province,Changsha 410008,China

出　　处：《International Journal of Bioprinting》索引2019年第5卷第1期,共25页

基　　金：This work was supported by the following funds:(1)The Natural Science Foundation of China(51575537,81572577,51705540);Hunan Provincial Natural Science Foundation of China(2016JJ1027);The Project of Innovation-driven Plan of Central South University(2016CX023);The Open-End Fund for the Valuable and Precision Instruments of Central South University;The fund of the State Key Laboratory of Solidification Processing in NWPU(SKLSP201605);National Postdoctoral Program for Innovative Talents(BX201700291);The Project of State Key Laboratory of High Performance Complex Manufacturing,Central South University;The Project of Hunan Provincial Science and Technology Plan(2017RS3008). 摘　　要：Additive manufacturing(AM)can obtain not only customized external shape but also porous internal structure for scaffolds,both of which are of great importance for repairing large segmental bone defects.The scaffold fabrication process generally involves scaffold design,AM,and post-treatments.Thus,this article firstly reviews the state-of-the-art of scaffold design,including computer-aided design,reverse modeling,topology optimization,and mathematical modeling.In addition,the current characteristics of several typical AM techniques,including selective laser sintering,fused deposition modeling(FDM),and electron beam melting(EBM),especially their advantages and limitations are presented.In particular,selective laser sintering is able to obtain scaffolds with nanoscale grains,due to its high heating rate and a short holding time.However,this character usually results in insufficient densification.FDM can fabricate scaffolds with a relative high accuracy of pore structure but with a relative low mechanical strength.EBM with a high beam-material coupling efficiency can process high melting point metals,but it exhibits a low-resolution and poor surface quality.Furthermore,the common post-treatments,with main focus on heat and surface treatments,which are applied to improve the comprehensive performance are also discussed.Finally,this review also discusses the future directions for AM scaffolds for bone tissue engineering. 关键词：ADDITIVE MANUFACTURING BONE scaffolds scaffolds DESIGN post-treatments

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Additive manufacturing of bone scaffolds

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