Intravenous infusion of magnesium sulfate is not associated with cardiovascular,liver,kidney,and metabolic toxicity in adults

查看全文 作　　者：Elisa [1]Karhu;Steven [1]E.Atlas;Jinrun [2]Gao;Syed [3]A.Mehdi;Dominique [3]Musselman;Sharon [4]Goldberg;Judi [1]M.Woolger;Raul [3]Corredor;Muhammad [3]H.Abbas;Leopoldo [1]Arosemena;Simone [1]Caccamo;Ashar [3]Farooqi;Janet [5]Konefal;Laura [3]Lantigua;Vanessa [3]Padilla;Ammar [3]Rasul;Eduard [3]Tiozzo;Oscar [3]L.Higuera;Andrea [3]Fiallo;John [3]E.Lewis 机构地区：[1]Departments of Medicine,Bay Harbor Islands,FL,USA;[2]Departments of Barclay’s,Inc.,Wilmington,DE,USA;[3]Departments of Psychiatry and Behavioral Sciences,Bay Harbor Islands,FL,USA;[4]Departments of Glow Health PA,Bay Harbor Islands,FL,USA;[5]Departments of Family Medicine and Community Health,University of Miami Miller School of Medicine,Miami,FL,USA 出　　处：《Journal of Clinical & Translational Research》索引2018年第4卷第1期,共9页 摘　　要：Background:Magnesium(Mg)deficiency contributes to the pathophysiology of numerous diseases.The therapeutic use of Mg has steadily increased over time.The increased in-hospital use of intravenous(IV)magnesium sulfate(MgSO4)warrants more extensive investigation regarding the safety of the therapy.The aim of this study was to determine the safety of IV MgSO4 infusion on cardiovascular,liver,kidney,and metabolic markers in adults.Methods:Twelve volunteers were randomized to one of two cross-over conditions:(a)IV infusion of MgSO4 in 5%dextrose followed by IV infusion of 5%dextrose 1 week later or(b)IV infusion of 5%dextrose followed by IV infusion of MgSO4 in 5%dextrose 1 week later.An electrocardiogram was recorded continuously during the infusions.Blood was drawn pre-and post-infusion for blood count(high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,and triglycerides).Results:Serum Mg increased from pre-to post-infusion in the MgSO4+5%dextrose group(p<0.0001).The QRS interval length increased from pre-to post-infusion in the MgSO4+5%dextrose group(p<0.04).Additionally,serum glucose concentration increased in the MgSO4+5%dextrose group(p=0.04).These significant findings were modeled with gender and age as covariates.No other significant differences were found.Conclusions:The administration of IV infusion of MgSO4(4 g/100 mL)in 5%dextrose over a 4-hour treatment period poses no significant deleterious effects on cardiovascular,liver,kidney,or metabolic function.Relevance for patients:IV infusion of MgSO4 may be used for certain treatment indications without significant concern for systemic or organ toxicity. 关 键 词：MgSO4 clinical PHARMACOLOGY drug TOXICITY