Printing amphotericin B on microneedles using matrixassisted pulsed laser evaporation

查看全文 作　　者：Roger [1]Sachan;Panupong [2]Jaipan;Jennifer [3]Y.Zhang;Simone [3]Degan;Detlev [4]Erdmann;Jonathan [5]Tedesco;Lyndsi [6]Vanderwal;Shane [6]J.Stafslien;Irina [7]Negut;Anita [7]Visan;Gabriela [7]Dorcioman;Gabriel [7]Socol;Rodica [7]Cristescu;Douglas [8]B.Chrisey;Roger [2]J.Narayan

机构地区：[1]Wake Early College of Health and Sciences,Raleigh,North Carolina,USA;[2]Joint Department of Biomedical Engineering,The University of North Carolina and North Carolina State University,Raleigh,North Carolina,USA;[3]Department of Dermatology,Duke University Medical Center,Durham,North Carolina,USA;[4]Department of Surgery,Division of Plastic,Reconstructive,Maxillofacial and Oral Surgery,Duke University Medical Center,Durham,North Carolina,USA;[5]Keyence Corporation of America,Elmwood Park,New Jersey,USA;[6]Office of Research and Creativity Activity,North Dakota State University,1715 Research Park Drive,Fargo ND,USA;[7]National Institute for Lasers,Plasma and Radiation Physics,Lasers Department,P.O.Box MG-36,Bucharest-Magurele,Romania;[8]Department of Physics and Engineering Physics,Tulane University,New Orleans,LA,USA

出　　处：《International Journal of Bioprinting》索引2017年第3卷第2期,共11页

基　　金：We would like to acknowledge C Mooney(NCSU Analytical Instrumentation Facility)for his aid with electron microscopy,B Andersen for her aid with Fourier transform infared spectrosocpy(NCSU College of Textiles),P Strader(NCSU Analytical Instrumentation Facility)for his aid with nanoindentation;the US National Institutes of Health(Award#1R21AI117748-01A1);the US National Science Foundation(Award CMMI 1258536);and the US Office of Naval Research(Award#N00014-15-1-2323);This work was also supported by the National Program PN 4N/2016(1647-LAPLASⅣand a grant of Ministry of Research and Innovation,CNCS–UEFISCDI,Project Number PNIII-P4-ID-PCE-2016-0884,within PNCDIⅢ. 摘　　要：Transdermal delivery of amphotericin B,a pharmacological agent with activity against fungi and parasitic protozoa,is a challenge since amphotericin B exhibits poor solubility in aqueous solutions at physiologic pH values.In this study,we have used a laser-based printing approach known as matrix-assisted pulsed laser evaporation to print amphotericin B on the surfaces of polyglycolic acid microneedles that were prepared using a combination of injection molding and drawing lithography.In a modified agar disk diffusion assay,the amphotericin B-loaded microneedles showed concentrationdependent activity against the yeast Candida albicans.The results of this study suggest that matrix-assisted pulsed laser evaporation may be used to print amphotericin B and other drugs that have complex solubility issues on the surfaces of microneedles. 关键词：matrix-assisted pulsed laser EVAPORATION MICRONEEDLE AMPHOTERICIN B ANTIFUNGAL

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Printing amphotericin B on microneedles using matrixassisted pulsed laser evaporation

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