HDAC-dependent decrease in histone crotonylation during DNA damage

查看全文 作　　者：Enas R.A bu-[1]Zhayia;Feras [1]E.Machour;Nabieh [1]Ayoub

机构地区：[1]Department of Biology,Technion-lsrael Institute of Technology,Haifa 3200003,Israel

出　　处：《Journal of Molecular Cell Biology》索引2019年第11卷第9期,共3页

摘　　要：Dear Editor,The DNA damage response(DDR)ensures repair of DNA lesions caused by endogenous and exogenous mutagens that constantly threaten genomic integrity.Defective DDR results in accumulation of DNA lesions that could potentially lead to genomic instability and tumorigenesis.Posttranslational modifications(PTMs)including phosphorylation,methylation,acetylation,ubiquitination,and sumoylation play a central role in sensing,signaling,and repairing damaged DNA. 关键词：DDR damage constantly

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HDAC-dependent decrease in histone crotonylation during DNA damage

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