Advancing antimicrobial strategies for managing oral biofilm infections

查看全文 作　　者：Yang [1]Jiao;Franklin [2]RTay;Li-na [3]Niu;Ji-hua [3]Chen

机构地区：[1]Department of Stomatology,the 7th Medical Center of PLA General Hospital,Beijing,China;[2]Department of Endodontics,the Dental College of Georgia,Augusta University,Augusta,GA,USA;[3]State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Oral Diseases,Department of Prosthodontics,School of Stomatology,the Fourth Military Medical University,Xi’an,China

出　　处：《International Journal of Oral Science》索引2019年第11卷第4期,共11页

基　　金：supported by grant from the Open Project from State Key Laboratory of Military Stomatology(No.2018KA02);National Key Research&Development Program of China(2017YFC0840100 and 2017YFC0840109);National Natural Science Foundation of China(81720108011);program for Changjiang Scholars and Innovative Research Team in University(No.IRT13051) 摘　　要：Effective control of oral biofilm infectious diseases represents a major global challenge.Microorganisms in biofilms exhibit increased drug tolerance compared with planktonic cells.The present review covers innovative antimicrobial strategies for controlling oral biofilm-related infections published predominantly over the past 5 years.Antimicrobial dental materials based on antimicrobial agent release,contact-killing and multi-functional strategies have been designed and synthesized for the prevention of initial bacterial attachment and subsequent biofilm formation on the tooth and material surface.Among the therapeutic approaches for managing biofilms in clinical practice,antimicrobial photodynamic therapy has emerged as an alternative to antimicrobial regimes and mechanical removal of biofilms,and cold atmospheric plasma shows significant advantages over conventional antimicrobial approaches.Nevertheless,more preclinical studies and appropriately designed and well-structured multi-center clinical trials are critically needed to obtain reliable comparative data.The acquired information will be helpful in identifying the most effective antibacterial solutions and the most optimal circumstances to utilize these strategies. 关键词：PREVENTION utilize ANTIMICROBIAL

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Advancing antimicrobial strategies for managing oral biofilm infections

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