Adipose stromal/stem cells in regenerative medicine:Potentials and limitations

查看全文 作　　者：Leandra Santos [1,2,3,4]Baptista

机构地区：[1]Multidisciplinary Center for Biological Research (Numpex-Bio),Federal University of Rio de Janeiro (UFRJ) Campus Duque de Caxias;[2]Post-graduate Program in Biotechnology,National Institute of Metrology,Quality and Technology (INMETRO);[3]Post-graduate Program in Translational Biomedicine (Biotrans),Unigranrio,Campus Ⅰ;[4]Laboratory of Tissue Bioengineering,Directory of Metrology Applied to Life Sciences,National Institute of Metrology,Quality and Technology(INMETRO)

出　　处：《World Journal of Stem Cells》索引2020年第12卷第1期,共7页

基　　金：Supported by the Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro(FAPERJ),No.E-26/202.682/2018 摘　　要：This article presents the stem and progenitor cells from subcutaneous adipose tissue,briefly comparing them with their bone marrow counterparts,and discussing their potential for use in regenerative medicine.Subcutaneous adipose tissue differs from other mesenchymal stromal/stem cells(MSCs)sources in that it contains a pre-adipocyte population that dwells in the adventitia of robust blood vessels.Pre-adipocytes are present both in the stromal-vascular fraction(SVF;freshly isolated cells)and in the adherent fraction of adipose stromal/stem cells(ASCs;in vitro expanded cells),and have an active role on the chronic inflammation environment established in obesity,likely due their monocyticmacrophage lineage identity.The SVF and ASCs have been explored in cell therapy protocols with relative success,given their paracrine and immunomodulatory effects.Importantly,the widely explored multipotentiality of ASCs has direct application in bone,cartilage and adipose tissue engineering.The aim of this editorial is to reinforce the peculiarities of the stem and progenitor cells from subcutaneous adipose tissue,revealing the spheroids as a recently described biotechnological tool for cell therapy and tissue engineering.Innovative cell culture techniques,in particular 3D scaffold-free cultures such as spheroids,are now available to increase the potential for regeneration and differentiation of mesenchymal lineages.Spheroids are being explored not only as a model for cell differentiation,but also as powerful 3D cell culture tools to maintain the stemness and expand the regenerative and differentiation capacities of mesenchymal cell lineages. 关键词：Mesenchymal stromal/stem cells Subcutaneous adipose tissue Stromalvascular fraction Adipose stromal/stem cells Regenerative medicine Cell therapy Tissue engineering SPHEROIDS

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Adipose stromal/stem cells in regenerative medicine:Potentials and limitations

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