Materials evolution of bone plates for internal fixation of bone fractures:A review

查看全文 作　　者：Junlei [1]Li;Ling [2,3]Qin;Ke [4]Yang;Zhijie [1]Ma;Yongxuan [1]Wang;Liangliang [1]Cheng;Dewei [1]Zhao

机构地区：[1]Department of Orthopaedics,Affiliated Zhongshan Hospital of Dalian University,Dalian,116001,China;[2]Musculoskeletal Research Laboratory of Department of Orthopaedics&Traumatology,The Chinese University of Hong Kong,Hong Kong SAR,China;[3]Center for Translational Medicine Research and Development,Institute of Biomedical Engineering,Chinese Academy of Sciences,Shenzhen,518055,China;[4]Institute of Metal Research,Chinese Academy of Sciences,Shenyang,110016,China

出　　处：《Journal of Materials Science & Technology》索引2020年第36卷第1期,共19页

基　　金：supported by the National Key R&D Program of China(Grant No.2016YFC1102000);the National Natural Science Foundation of China(Grant Nos.81672139 and 81702129);the China Postdoctoral Science Foundation(No.171479);Doctor Initial Foundation of Liaoning Province(No.20170520017);Affiliated Zhongshan Hospital of Dalian University(No.DLDXZSYYDK201701);by a grant from the Research Grants Council of the Hong Kong Special Administrative Region,China(Project No.T13-402/17-N)。 摘　　要：Bone plates play a vital role in bone fracture healing by providing the necessary mechanical fixation for fracture fragments through modulating biomechanical microenvironment adjacent to the fracture site.Good treatment effect has been achieved for fixation of bone fracture with conventional bone plates,which are made of stainless steel or titanium alloy.However,several limitations still exist with traditional bone plates including loosening and stress shielding due to significant difference in modulus between metal material and bone tissue that impairs optimal fracture healing.Additionally,due to demographic changes and non-physiological loading,the population suffering from refractory fractures,such as osteoporosis fractures and comminuted fractures,is increasing,which imposes a big challenge to traditional bone plates developed for normal bone fracture repair.Therefore,optimal fracture treatment with adequate fixation implants in terms of materials and design relevant to special conditions is desirable.In this review,the complex physiological process of bone healing is introduced,followed by reviewing the development of implant design and biomaterials for bone plates.Finally,we discuss recent development of hybrid bone plates that contains bioactive elements or factors for fracture healing enhancement as a promising direction.This includes biodegradable Mg-based alloy used for designing bone screw-plates that has been proven to be beneficial for fracture healing,an innovative development that attracts more and more attention.This paper also indicates that the tantalum bone plates with porous structure are also emerging as a new fracture internal fixation implants.The reduction of the stress shielding is verified to be useful to accelerate bone fracture healing.Potential application of biodegradable metals may also avoid a second operation for implant removal.Further developments in biometals and their design for orthopedic bone plates are expected to improve the treatment of bone fracture,especially the refractory fractures. 关键词：BONE plate BIOMATERIALS BIODEGRADABLE MATERIALS Titanium MAGNESIUM Porous TANTALUM

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Materials evolution of bone plates for internal fixation of bone fractures:A review

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